Attempted suicide and alcoholism in bipolar disorder: Clinical and familial relationships

James Bennett Potash, H. S. Kane, Y. F. Chiu, S. G. Simpson, Dean F Mackinnon, M. G. McInnis, F. J. McMahon, J Raymond Depaulo

Research output: Contribution to journalArticle

Abstract

Objective: This study examined the clinical and familial relationships between comorbid alcoholism and attempted suicide in affectively ill relatives of probands with bipolar I disorder. Method: In 71 families ascertained for a genetic linkage study, 337 subjects with major affective disorder were assessed by using the Schedule for Affective Disorders and Schizophrenia - Lifetime Version. Results: Subjects with bipolar disorder and alcoholism had a 38.4% lifetime rate of attempted suicide, whereas those without alcoholism had a 21.7% rate. Attempted suicide among subjects with bipolar disorder and alcoholism clustered in a subset of seven families. Families with alcoholic and suicidal probands had a 40.7% rate of attempted suicide in first-degree relatives with bipolar disorder, whereas other families had a 19.0% rate. Conclusions: Comorbid alcoholism was associated with a higher rate of attempted suicide among family members with bipolar disorder. Attempted suicide and alcoholism clustered in a subset of families. These relationships may have a genetic origin and may be mediated by intoxication, mixed states, and/or temperamental instability.

Original languageEnglish (US)
Pages (from-to)2048-2050
Number of pages3
JournalAmerican Journal of Psychiatry
Volume157
Issue number12
DOIs
StatePublished - 2000

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Attempted Suicide
Bipolar Disorder
Alcoholism
Mood Disorders
Genetic Linkage
Schizophrenia
Appointments and Schedules

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Attempted suicide and alcoholism in bipolar disorder : Clinical and familial relationships. / Potash, James Bennett; Kane, H. S.; Chiu, Y. F.; Simpson, S. G.; Mackinnon, Dean F; McInnis, M. G.; McMahon, F. J.; Depaulo, J Raymond.

In: American Journal of Psychiatry, Vol. 157, No. 12, 2000, p. 2048-2050.

Research output: Contribution to journalArticle

Potash, James Bennett ; Kane, H. S. ; Chiu, Y. F. ; Simpson, S. G. ; Mackinnon, Dean F ; McInnis, M. G. ; McMahon, F. J. ; Depaulo, J Raymond. / Attempted suicide and alcoholism in bipolar disorder : Clinical and familial relationships. In: American Journal of Psychiatry. 2000 ; Vol. 157, No. 12. pp. 2048-2050.
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