A double blind study was conducted to test the prophylactic effect of a nonabsorbable broad spectrum antimicrobial (oral colistin sulfate) against acute diarrhea in Apache children. Children 1 to 6 mth old had over twice the morbidity from diarrhea if assigned to the antimicrobial group as compared to placebo, while the toddler group (7 to 30 mth) taking the antimicrobial had somewhat less diarrhea. Enteropathogenic E. coli was significantly more often isolated from the antimicrobial group (but only in well children). No special effect on the children's growth by the antimicrobial was discerned.
ASJC Scopus subject areas
- Infectious Diseases