Atrophy of skeletal muscle in chick embryos treated with botulinum toxin

Research output: Contribution to journalArticle

Abstract

Botulinum toxin was given in large intravenous doses to 7- and 12- day chick embryos. Atrophy of skeletal muscle resulted without significant atrophy of other organs. The histological appearance of muscle was consistent with denervation. The results suggest that neural acetylcholine release may play a significant role in "trophic transmission" from nerve to muscle.

Original languageEnglish (US)
Pages (from-to)719-721
Number of pages3
JournalScience
Volume145
Issue number3633
DOIs
StatePublished - Jan 1 1964
Externally publishedYes

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