Atrophy Limited to the Third Ventricle in Chronic Schizophrenic Patients: Report of a Controlled Series

John Boronow, David Pickar, Philip T. Ninan, Alec Roy, Daniel Hommer, Markku Linnoila, Steven M. Paul

Research output: Contribution to journalArticle

Abstract

Computed tomographic scans of 30 chronic schizophrenic patients and 26 matched medical controls were blindly assessed for ventricular brain ratio, cortical atrophy, thirdventricle diameter, and cerebellar atrophy. Schizophrenic tients had significantly larger third ventricles than the medical controls. There was no difference in the other brain morphologic variables. Phenomenology, drug response, CSF levels of 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, and a wide variety of clinical variables did not correlate with any measure of brain morphology. Clinicopathologic correlates of brain morphology may be limited to those patients with significant atrophy.

Original languageEnglish (US)
Pages (from-to)266-271
Number of pages6
JournalArchives of General Psychiatry
Volume42
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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