TY - JOUR
T1 - Atrophy Limited to the Third Ventricle in Chronic Schizophrenic Patients
T2 - Report of a Controlled Series
AU - Boronow, John
AU - Pickar, David
AU - Ninan, Philip T.
AU - Roy, Alec
AU - Hommer, Daniel
AU - Linnoila, Markku
AU - Paul, Steven M.
PY - 1985
Y1 - 1985
N2 - Computed tomographic scans of 30 chronic schizophrenic patients and 26 matched medical controls were blindly assessed for ventricular brain ratio, cortical atrophy, thirdventricle diameter, and cerebellar atrophy. Schizophrenic tients had significantly larger third ventricles than the medical controls. There was no difference in the other brain morphologic variables. Phenomenology, drug response, CSF levels of 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, and a wide variety of clinical variables did not correlate with any measure of brain morphology. Clinicopathologic correlates of brain morphology may be limited to those patients with significant atrophy.
AB - Computed tomographic scans of 30 chronic schizophrenic patients and 26 matched medical controls were blindly assessed for ventricular brain ratio, cortical atrophy, thirdventricle diameter, and cerebellar atrophy. Schizophrenic tients had significantly larger third ventricles than the medical controls. There was no difference in the other brain morphologic variables. Phenomenology, drug response, CSF levels of 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, and a wide variety of clinical variables did not correlate with any measure of brain morphology. Clinicopathologic correlates of brain morphology may be limited to those patients with significant atrophy.
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U2 - 10.1001/archpsyc.1985.01790260060007
DO - 10.1001/archpsyc.1985.01790260060007
M3 - Article
C2 - 2579616
AN - SCOPUS:0021838360
SN - 0003-990X
VL - 42
SP - 266
EP - 271
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 3
ER -