Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal

Research output: Contribution to journalReview articlepeer-review

Abstract

CaMKII is a serine-threonine protein kinase that is abundant in myocardium. Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, calcium homeostasis, matrix remodelling, inflammation, and metabolism. Furthermore, CaMKII inhibition appears to protect against AF in animal models and correct proarrhythmic, defective intracellular Ca2+ homeostasis in fibrillating human atrial cells. This review considers current concepts and evidence from animal and human studies on the role of CaMKII in AF.

Original languageEnglish (US)
Pages (from-to)542-557
Number of pages16
JournalCardiovascular research
Volume109
Issue number4
DOIs
StatePublished - Apr 1 2016

Keywords

  • Arrhythmias
  • Atrial fibrillation
  • Atrial remodelling
  • CaMKII

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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