Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal

Olurotimi O. Mesubi; Mark E. Anderson

doi:10.1093/cvr/cvw002

Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal

Olurotimi O. Mesubi, Mark E. Anderson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

CaMKII is a serine-threonine protein kinase that is abundant in myocardium. Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, calcium homeostasis, matrix remodelling, inflammation, and metabolism. Furthermore, CaMKII inhibition appears to protect against AF in animal models and correct proarrhythmic, defective intracellular Ca²⁺ homeostasis in fibrillating human atrial cells. This review considers current concepts and evidence from animal and human studies on the role of CaMKII in AF.

Original language	English (US)
Pages (from-to)	542-557
Number of pages	16
Journal	Cardiovascular research
Volume	109
Issue number	4
DOIs	https://doi.org/10.1093/cvr/cvw002
State	Published - Apr 1 2016

Keywords

Arrhythmias
Atrial fibrillation
Atrial remodelling
CaMKII

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/cvr/cvw002

Cite this

@article{6e1da90ad9b544ba82435db47ee23409,

title = "Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal",

abstract = "CaMKII is a serine-threonine protein kinase that is abundant in myocardium. Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, calcium homeostasis, matrix remodelling, inflammation, and metabolism. Furthermore, CaMKII inhibition appears to protect against AF in animal models and correct proarrhythmic, defective intracellular Ca2+ homeostasis in fibrillating human atrial cells. This review considers current concepts and evidence from animal and human studies on the role of CaMKII in AF.",

keywords = "Arrhythmias, Atrial fibrillation, Atrial remodelling, CaMKII",

author = "Mesubi, {Olurotimi O.} and Anderson, {Mark E.}",

year = "2016",

month = apr,

day = "1",

doi = "10.1093/cvr/cvw002",

language = "English (US)",

volume = "109",

pages = "542--557",

journal = "Cardiovascular research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Atrial remodelling in atrial fibrillation

T2 - CaMKII as a nodal proarrhythmic signal

AU - Mesubi, Olurotimi O.

AU - Anderson, Mark E.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - CaMKII is a serine-threonine protein kinase that is abundant in myocardium. Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, calcium homeostasis, matrix remodelling, inflammation, and metabolism. Furthermore, CaMKII inhibition appears to protect against AF in animal models and correct proarrhythmic, defective intracellular Ca2+ homeostasis in fibrillating human atrial cells. This review considers current concepts and evidence from animal and human studies on the role of CaMKII in AF.

AB - CaMKII is a serine-threonine protein kinase that is abundant in myocardium. Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, calcium homeostasis, matrix remodelling, inflammation, and metabolism. Furthermore, CaMKII inhibition appears to protect against AF in animal models and correct proarrhythmic, defective intracellular Ca2+ homeostasis in fibrillating human atrial cells. This review considers current concepts and evidence from animal and human studies on the role of CaMKII in AF.

KW - Arrhythmias

KW - Atrial fibrillation

KW - Atrial remodelling

KW - CaMKII

UR - http://www.scopus.com/inward/record.url?scp=84964227446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964227446&partnerID=8YFLogxK

U2 - 10.1093/cvr/cvw002

DO - 10.1093/cvr/cvw002

M3 - Review article

C2 - 26762270

AN - SCOPUS:84964227446

SN - 0008-6363

VL - 109

SP - 542

EP - 557

JO - Cardiovascular research

JF - Cardiovascular research

IS - 4

ER -

Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this