Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose

Peter Brust, Alexander Baethmann, Albert Gjedde, Armin Ermisch

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Recent evidence predicts an effect of atrial natriuretic peptide (ANP) on the blood-brain transfer of water. To test this prediction, we measured the blood-brain transfer of water, l-leucine, and d-glucose in 9 brain regions of male rats after intravenous injection of 10 pmol ANP. The peptide elicited an increase of the permeability-surface area (PaS) product of labeled water by 28-108% while the PaS products of leucine and glucose remained unchanged. Cerebral blood flow incresed 15-48% while cardiac output and plasma volume in brain did not alter, indicating no change of capillary surface area (CSA). Regionally, the CSA varied from 63 cm2/g (striatum) to 97 cm2/g (colliculi) and the fraction of capillaries contributing to the total vascular volume varied from 29% (olfactory bulb/lobe) to 62% (striatum). The blood-brain barrier (BBB) permeability to water (5.7 μm/s) was an order of magnitude higher than to glucose (0.4 μm/s) or to leucine (0.3 μm/s).

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalBrain research
Issue number1
StatePublished - Nov 8 1991


  • Blood-brain barrier
  • Brain edema
  • Cerebral blood flow
  • Endothelial cell
  • Permeability
  • Surface area
  • Transport

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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