Abstract
Recent evidence predicts an effect of atrial natriuretic peptide (ANP) on the blood-brain transfer of water. To test this prediction, we measured the blood-brain transfer of water, l-leucine, and d-glucose in 9 brain regions of male rats after intravenous injection of 10 pmol ANP. The peptide elicited an increase of the permeability-surface area (PaS) product of labeled water by 28-108% while the PaS products of leucine and glucose remained unchanged. Cerebral blood flow incresed 15-48% while cardiac output and plasma volume in brain did not alter, indicating no change of capillary surface area (CSA). Regionally, the CSA varied from 63 cm2/g (striatum) to 97 cm2/g (colliculi) and the fraction of capillaries contributing to the total vascular volume varied from 29% (olfactory bulb/lobe) to 62% (striatum). The blood-brain barrier (BBB) permeability to water (5.7 μm/s) was an order of magnitude higher than to glucose (0.4 μm/s) or to leucine (0.3 μm/s).
Original language | English (US) |
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Pages (from-to) | 91-96 |
Number of pages | 6 |
Journal | Brain research |
Volume | 564 |
Issue number | 1 |
DOIs | |
State | Published - Nov 8 1991 |
Keywords
- Blood-brain barrier
- Brain edema
- Cerebral blood flow
- Endothelial cell
- Permeability
- Surface area
- Transport
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology