@article{a4f405e0d10947f5972bf6827f6daf9f,
title = "Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD",
abstract = "Background: Studies in the general population suggest that atrial fibrillation (AF) is an independent risk factor for decline in cognitive function, but this relationship has not been examined in adults with chronic kidney disease (CKD). We investigated the association between incident AF and changes in cognitive function over time in this population. Methods and Results: We studied a subgroup of 3254 adults participating in the Chronic Renal Insufficiency Cohort Study. Incident AF was ascertained by 12-lead electrocardiogram (ECG) obtained at a study visit and/or identification of a hospitalization with AF during follow-up. Cognitive function was assessed biennially using the Modified Mini-Mental State Exam. Linear mixed effects regression was used to evaluate the association between incident AF and longitudinal change in cognitive function. Compared with individuals without incident AF (n = 3158), those with incident AF (n = 96) were older, had a higher prevalence of cardiovascular disease and hypertension, and lower estimated glomerular filtration rate. After median follow-up of 6.8 years, we observed no significant multivariable association between incident AF and change in cognitive function test score. Conclusion: In this cohort of adults with CKD, incident AF was not associated with a decline in cognitive function.",
keywords = "atrial fibrillation, cognitive function, nephrology and kidney",
author = "{CRIC Study Investigators} and McCauley, {Mark D.} and Hsu, {Jesse Y.} and Ricardo, {Ana C.} and Dawood Darbar and Mayank Kansal and {Kurella Tamura}, Manjula and Feldman, {Harold I.} and Kusek, {John W.} and Taliercio, {Jonathan J.} and Rao, {Panduranga S.} and Tariq Shafi and Jiang He and Xue Wang and Daohang Sha and Melissa Lamar and Go, {Alan S.} and Kristine Yaffe and Lash, {James P.} and Appel, {Lawrence J.} and Mahboob Rahman and Townsend, {Raymond R.}",
note = "Funding Information: Funding for the CRIC Study was obtained under a cooperative agreement from National Institute of Diabetes and Digestive and Kidney Diseases (U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, and U01DK060902). In addition, this work was supported in part by the Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Science Award National Institutes of Health (NIH)/ National Center for Advancing Translational Sciences (NCATS) UL1TR000003, Johns Hopkins University UL1 TR-000424, University of Maryland GCRC M01 RR-16500, Clinical and Translational Science Collaborative of Cleveland , UL1TR000439 from the NCATS component of NIH and NIH roadmap for Medical Research, Michigan Institute for Clinical and Health Research (MICHR) UL1TR000433, University of Illinois at Chicago CTSA UL1RR029879, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases P20 GM109036, Kaiser Permanente NIH/NCRR UCSF-CTSI UL1 RR-024131. MDM is funded by National Heart, Lung, and Blood Institute (NHLBI) K08-HL130587 and NHLBI R01-HL151508. JPL is funded by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K24DK092290 and R01-DK072231-91. ACR is funded by the NIDDK R01DK118736. DD is funded by NHLBI R01 HL138737, R01 HL150586, T32 HL139439, and Merit Review Award I01 BX004268 of the U.S. Department of Veterans Affairs BLRD Service. Publisher Copyright: {\textcopyright} 2021 International Society of Nephrology",
year = "2021",
month = mar,
doi = "10.1016/j.ekir.2020.12.023",
language = "English (US)",
volume = "6",
pages = "669--674",
journal = "Kidney International Reports",
issn = "2468-0249",
publisher = "Elsevier Inc.",
number = "3",
}