Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities

Jeremy P. Berman, Faye L. Norby, Thomas Mosley, Elsayed Z. Soliman, Rebecca F Gottesman, Pamela L. Lutsey, Alvaro Alonso, Lin Y. Chen

Research output: Contribution to journalArticle

Abstract

Background and Purpose- Atrial fibrillation (AF) is associated with dementia independent of clinical stroke. The mechanisms underlying this association remain unclear. In a community-based cohort, the ARIC study (Atherosclerosis Risk in Communities), we evaluated (1) the longitudinal association of incident AF and (2) the cross-sectional association of prevalent AF with brain magnetic resonance imaging (MRI) abnormalities. Methods- The longitudinal analysis included 963 participants (mean age, 73±4.4 years; 62% women; 51% black) without prevalent stroke or AF who underwent a brain MRI in 1993 to 1995 and a second MRI in 2004 to 2006 (mean, 10.6±0.8 years). Outcomes included subclinical cerebral infarctions, sulcal size, ventricular size, and, for the cross-sectional analysis, white matter hyperintensity volume and total brain volume. Results- In the longitudinal analysis, 29 (3.0%) participants developed AF after the first brain MRI. Those who developed AF had higher odds of increase in subclinical cerebral infarctions (odds ratio [OR], 3.08; 95% CI, 1.39-6.83), worsening sulcal grade (OR, 3.56; 95% CI, 1.04-12.2), and worsening ventricular grade (OR, 9.34; 95% CI, 1.24-70.2). In cross-sectional analysis, of 969 participants, 35 (3.6%) had prevalent AF at the time of the 2004 to 2006 MRI scan. Those with AF had greater odds of higher sulcal (OR, 3.9; 95% CI, 1.7-9.1) and ventricular grade (OR, 2.4; 95% CI, 1.0-5.7) after multivariable adjustment and no difference in white matter hyperintensity or total brain volume. Conclusions- AF is independently associated with increase in subclinical cerebral infarction and worsening sulcal and ventricular grade-morphological changes associated with aging and dementia. More research is needed to define the mechanisms underlying AF-related neurodegeneration.

Original languageEnglish (US)
Pages (from-to)783-788
Number of pages6
JournalStroke
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Atrial Fibrillation
Magnetic Resonance Imaging
Brain
Odds Ratio
Cerebral Infarction
Dementia
Cross-Sectional Studies
Stroke
Social Adjustment
Atherosclerosis
Cohort Studies
Research

Keywords

  • atrial fibrillation
  • cognitive dysfunction
  • dementia
  • magnetic resonance imaging
  • research

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Berman, J. P., Norby, F. L., Mosley, T., Soliman, E. Z., Gottesman, R. F., Lutsey, P. L., ... Chen, L. Y. (2019). Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities. Stroke, 50(4), 783-788. https://doi.org/10.1161/STROKEAHA.118.024143

Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities. / Berman, Jeremy P.; Norby, Faye L.; Mosley, Thomas; Soliman, Elsayed Z.; Gottesman, Rebecca F; Lutsey, Pamela L.; Alonso, Alvaro; Chen, Lin Y.

In: Stroke, Vol. 50, No. 4, 01.04.2019, p. 783-788.

Research output: Contribution to journalArticle

Berman, JP, Norby, FL, Mosley, T, Soliman, EZ, Gottesman, RF, Lutsey, PL, Alonso, A & Chen, LY 2019, 'Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities', Stroke, vol. 50, no. 4, pp. 783-788. https://doi.org/10.1161/STROKEAHA.118.024143
Berman JP, Norby FL, Mosley T, Soliman EZ, Gottesman RF, Lutsey PL et al. Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities. Stroke. 2019 Apr 1;50(4):783-788. https://doi.org/10.1161/STROKEAHA.118.024143
Berman, Jeremy P. ; Norby, Faye L. ; Mosley, Thomas ; Soliman, Elsayed Z. ; Gottesman, Rebecca F ; Lutsey, Pamela L. ; Alonso, Alvaro ; Chen, Lin Y. / Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities. In: Stroke. 2019 ; Vol. 50, No. 4. pp. 783-788.
@article{247cd96cc5c84edd9b70070cfa234980,
title = "Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities",
abstract = "Background and Purpose- Atrial fibrillation (AF) is associated with dementia independent of clinical stroke. The mechanisms underlying this association remain unclear. In a community-based cohort, the ARIC study (Atherosclerosis Risk in Communities), we evaluated (1) the longitudinal association of incident AF and (2) the cross-sectional association of prevalent AF with brain magnetic resonance imaging (MRI) abnormalities. Methods- The longitudinal analysis included 963 participants (mean age, 73±4.4 years; 62{\%} women; 51{\%} black) without prevalent stroke or AF who underwent a brain MRI in 1993 to 1995 and a second MRI in 2004 to 2006 (mean, 10.6±0.8 years). Outcomes included subclinical cerebral infarctions, sulcal size, ventricular size, and, for the cross-sectional analysis, white matter hyperintensity volume and total brain volume. Results- In the longitudinal analysis, 29 (3.0{\%}) participants developed AF after the first brain MRI. Those who developed AF had higher odds of increase in subclinical cerebral infarctions (odds ratio [OR], 3.08; 95{\%} CI, 1.39-6.83), worsening sulcal grade (OR, 3.56; 95{\%} CI, 1.04-12.2), and worsening ventricular grade (OR, 9.34; 95{\%} CI, 1.24-70.2). In cross-sectional analysis, of 969 participants, 35 (3.6{\%}) had prevalent AF at the time of the 2004 to 2006 MRI scan. Those with AF had greater odds of higher sulcal (OR, 3.9; 95{\%} CI, 1.7-9.1) and ventricular grade (OR, 2.4; 95{\%} CI, 1.0-5.7) after multivariable adjustment and no difference in white matter hyperintensity or total brain volume. Conclusions- AF is independently associated with increase in subclinical cerebral infarction and worsening sulcal and ventricular grade-morphological changes associated with aging and dementia. More research is needed to define the mechanisms underlying AF-related neurodegeneration.",
keywords = "atrial fibrillation, cognitive dysfunction, dementia, magnetic resonance imaging, research",
author = "Berman, {Jeremy P.} and Norby, {Faye L.} and Thomas Mosley and Soliman, {Elsayed Z.} and Gottesman, {Rebecca F} and Lutsey, {Pamela L.} and Alvaro Alonso and Chen, {Lin Y.}",
year = "2019",
month = "4",
day = "1",
doi = "10.1161/STROKEAHA.118.024143",
language = "English (US)",
volume = "50",
pages = "783--788",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities

AU - Berman, Jeremy P.

AU - Norby, Faye L.

AU - Mosley, Thomas

AU - Soliman, Elsayed Z.

AU - Gottesman, Rebecca F

AU - Lutsey, Pamela L.

AU - Alonso, Alvaro

AU - Chen, Lin Y.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background and Purpose- Atrial fibrillation (AF) is associated with dementia independent of clinical stroke. The mechanisms underlying this association remain unclear. In a community-based cohort, the ARIC study (Atherosclerosis Risk in Communities), we evaluated (1) the longitudinal association of incident AF and (2) the cross-sectional association of prevalent AF with brain magnetic resonance imaging (MRI) abnormalities. Methods- The longitudinal analysis included 963 participants (mean age, 73±4.4 years; 62% women; 51% black) without prevalent stroke or AF who underwent a brain MRI in 1993 to 1995 and a second MRI in 2004 to 2006 (mean, 10.6±0.8 years). Outcomes included subclinical cerebral infarctions, sulcal size, ventricular size, and, for the cross-sectional analysis, white matter hyperintensity volume and total brain volume. Results- In the longitudinal analysis, 29 (3.0%) participants developed AF after the first brain MRI. Those who developed AF had higher odds of increase in subclinical cerebral infarctions (odds ratio [OR], 3.08; 95% CI, 1.39-6.83), worsening sulcal grade (OR, 3.56; 95% CI, 1.04-12.2), and worsening ventricular grade (OR, 9.34; 95% CI, 1.24-70.2). In cross-sectional analysis, of 969 participants, 35 (3.6%) had prevalent AF at the time of the 2004 to 2006 MRI scan. Those with AF had greater odds of higher sulcal (OR, 3.9; 95% CI, 1.7-9.1) and ventricular grade (OR, 2.4; 95% CI, 1.0-5.7) after multivariable adjustment and no difference in white matter hyperintensity or total brain volume. Conclusions- AF is independently associated with increase in subclinical cerebral infarction and worsening sulcal and ventricular grade-morphological changes associated with aging and dementia. More research is needed to define the mechanisms underlying AF-related neurodegeneration.

AB - Background and Purpose- Atrial fibrillation (AF) is associated with dementia independent of clinical stroke. The mechanisms underlying this association remain unclear. In a community-based cohort, the ARIC study (Atherosclerosis Risk in Communities), we evaluated (1) the longitudinal association of incident AF and (2) the cross-sectional association of prevalent AF with brain magnetic resonance imaging (MRI) abnormalities. Methods- The longitudinal analysis included 963 participants (mean age, 73±4.4 years; 62% women; 51% black) without prevalent stroke or AF who underwent a brain MRI in 1993 to 1995 and a second MRI in 2004 to 2006 (mean, 10.6±0.8 years). Outcomes included subclinical cerebral infarctions, sulcal size, ventricular size, and, for the cross-sectional analysis, white matter hyperintensity volume and total brain volume. Results- In the longitudinal analysis, 29 (3.0%) participants developed AF after the first brain MRI. Those who developed AF had higher odds of increase in subclinical cerebral infarctions (odds ratio [OR], 3.08; 95% CI, 1.39-6.83), worsening sulcal grade (OR, 3.56; 95% CI, 1.04-12.2), and worsening ventricular grade (OR, 9.34; 95% CI, 1.24-70.2). In cross-sectional analysis, of 969 participants, 35 (3.6%) had prevalent AF at the time of the 2004 to 2006 MRI scan. Those with AF had greater odds of higher sulcal (OR, 3.9; 95% CI, 1.7-9.1) and ventricular grade (OR, 2.4; 95% CI, 1.0-5.7) after multivariable adjustment and no difference in white matter hyperintensity or total brain volume. Conclusions- AF is independently associated with increase in subclinical cerebral infarction and worsening sulcal and ventricular grade-morphological changes associated with aging and dementia. More research is needed to define the mechanisms underlying AF-related neurodegeneration.

KW - atrial fibrillation

KW - cognitive dysfunction

KW - dementia

KW - magnetic resonance imaging

KW - research

UR - http://www.scopus.com/inward/record.url?scp=85063711994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063711994&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.118.024143

DO - 10.1161/STROKEAHA.118.024143

M3 - Article

VL - 50

SP - 783

EP - 788

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 4

ER -