ATPASE-POSITIVE EPIDERMALE LANGERHANS-ZELLEN: HEMMUNG DER ATPASE DURCH AMMONIUM-BITUMINOSULFONAT (ICHTHYOL) UND PIX LITHANTHRACIS

Translated title of the contribution: ATPase-positive epidermal Langerhans cells: Inhibition of the ATPase by ammonium bituminosulfonate (Ichthyol) and Pix lithanthracis

W. Diezel, S. Gruner, G. J. Anhalt

Research output: Contribution to journalArticle

Abstract

Both ammonium bituminosulfonate (Ichthyol) and Pix lithanthracis reduce the number of ATPase-positive epidermal Langerhans cells (ELC) in the epidermis of BALB/c mice: vaselinum flavum alone vs vaselinum flavum + 5% Ichthyol: P < 0.01; vaselinum flavum vs vaselinum flavum + 5% Pix lithanthracis: P < 0.001. In contrast to this, the number of Ia-positive cells was not changed under identical conditions. These results allow the conclusion that Ichthyol and Pix lithanthracis are able to inhibit the enzyme ATPase on the surface of ELC. We infer that inhibition of ELC ATPase may be important in the regulation of ELC function (inhibition of cutaneous contact hypersensitivity).

Original languageGerman
Pages (from-to)22-24
Number of pages3
JournalHautarzt
Volume43
Issue number1
StatePublished - Jan 1 1992
Externally publishedYes

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Keywords

  • ATPase activity
  • Ichthyol
  • Langerhans cells
  • Pix lithanthracis

ASJC Scopus subject areas

  • Dermatology

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