Atopic Dermatitis and the Role of the Skin Microbiome in Choosing Prevention, Treatment, and Maintenance Options

Hilary Baldwin, Crystal Aguh, Anneke Andriessen, Latanya Benjamin, Aaron S. Ferberg, Deirdre Hooper, Joseph L. Jarizzo, Peter A. Lio, Brook Tlougan, Heather C. Woolery-Lloyd, Joshua Zeichner

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Atopic dermatitis (AD) is a common skin condition characterized by disturbed barrier function, skin inflammation, and cutaneous dysbiosis. Clinically, it manifests as chronic-recurrent xerosis, pruritus, and erythematous lesions. Its pathophysiology is complex, making the selection of appropriate treatment options a task. AIM: To share insights gained from a literature review and discussions with experts in dermatology on key factors related to the prevention, treatment, and management of AD in relation to the skin microbiome. METHODS: Results from an expert panel were summarized and discussed to provide updated recommendations for the treatment and maintenance of AD. RESULTS: Evidence supports a strategy for managing inflammatory skin diseases with a selenium-rich post-biotic thermal water and biomass containing moisturizer. The moisturizer helps to restore homeostasis of the skin, re-populate a diverse microbiome, encourage the growth of commensal bacteria, and improve barrier function and symptoms of AD. CONCLUSIONS: Normalization of skin microbiome diversity using a topical moisturizer containing post-biotic aqua and biomass may offer a valuable option for the treatment and maintenance of inflammatory skin diseases. Clinicians should discuss the benefits of this treatment in the context of a full AD management program that covers prevention, active treatment, and maintenance. J Drugs Dermatol. 2020;19(10):935-940. doi:10.36849/JDD.2020.5393.

Original languageEnglish (US)
Pages (from-to)935-940
Number of pages6
JournalJournal of drugs in dermatology : JDD
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2020

ASJC Scopus subject areas

  • Dermatology

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