Atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI) on a quadrupole ion trap mass spectrometer

Susanne C. Moyer, Lisa A. Marzilli, Amina S. Woods, Victor V. Laiko, Vladimir M. Doroshenko, Robert J. Cotter

Research output: Contribution to journalArticle

Abstract

A new atmospheric pressure ionization technique, atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI), was recently introduced by Laiko et al. [U.S. Patent 5,965,884; Abstracts of the 4th International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, 25-29 August 1998; Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, TX, 1999; Anal. Chem. 72 (2000) 652]. This source has been coupled to an orthogonal time-of-flight mass spectrometer [U.S. Patent 5,965,884; Abstracts of the 4th International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, 25-29 August 1998; Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, TX, 1999; Anal. Chem. 72 (2000) 652] and to an ion trap mass spectrometer (ITMS) [Anal. Chem. 72 (2000) 5239; Atmospheric Pressure MALDI/Ion Trap Mass Spectrometry, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000; An Atmospheric Pressure MALDI Probe for Use with ESI Source Interfaces, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000; Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000]. Here, we present the current status of the work involving the development of an AP MALDI source for an ITMS. In addition, we present recent work from our own laboratory to demonstrate the utility of this novel configuration.

Original languageEnglish (US)
Pages (from-to)133-150
Number of pages18
JournalInternational Journal of Mass Spectrometry
Volume226
Issue number1
DOIs
StatePublished - Mar 15 2003

Fingerprint

Mass spectrometers
mass spectrometers
Atmospheric pressure
Ionization
Mass spectrometry
Desorption
atmospheric pressure
mass spectroscopy
quadrupoles
desorption
Ions
ionization
Lasers
matrices
lasers
congressional reports
beaches
Beaches
life sciences
patents

Keywords

  • Acetylation
  • AP MALDI
  • ITMS
  • Oligosaccharides
  • Phosphorylation
  • Protein digests
  • Proteins
  • Sulfation
  • Tandem mass spectrometry
  • Time-of-flight

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Spectroscopy

Cite this

Atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI) on a quadrupole ion trap mass spectrometer. / Moyer, Susanne C.; Marzilli, Lisa A.; Woods, Amina S.; Laiko, Victor V.; Doroshenko, Vladimir M.; Cotter, Robert J.

In: International Journal of Mass Spectrometry, Vol. 226, No. 1, 15.03.2003, p. 133-150.

Research output: Contribution to journalArticle

Moyer, Susanne C. ; Marzilli, Lisa A. ; Woods, Amina S. ; Laiko, Victor V. ; Doroshenko, Vladimir M. ; Cotter, Robert J. / Atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI) on a quadrupole ion trap mass spectrometer. In: International Journal of Mass Spectrometry. 2003 ; Vol. 226, No. 1. pp. 133-150.
@article{d051a2c8000d478bbd3528db66eed6b5,
title = "Atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI) on a quadrupole ion trap mass spectrometer",
abstract = "A new atmospheric pressure ionization technique, atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI), was recently introduced by Laiko et al. [U.S. Patent 5,965,884; Abstracts of the 4th International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, 25-29 August 1998; Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, TX, 1999; Anal. Chem. 72 (2000) 652]. This source has been coupled to an orthogonal time-of-flight mass spectrometer [U.S. Patent 5,965,884; Abstracts of the 4th International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, 25-29 August 1998; Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, TX, 1999; Anal. Chem. 72 (2000) 652] and to an ion trap mass spectrometer (ITMS) [Anal. Chem. 72 (2000) 5239; Atmospheric Pressure MALDI/Ion Trap Mass Spectrometry, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000; An Atmospheric Pressure MALDI Probe for Use with ESI Source Interfaces, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000; Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000]. Here, we present the current status of the work involving the development of an AP MALDI source for an ITMS. In addition, we present recent work from our own laboratory to demonstrate the utility of this novel configuration.",
keywords = "Acetylation, AP MALDI, ITMS, Oligosaccharides, Phosphorylation, Protein digests, Proteins, Sulfation, Tandem mass spectrometry, Time-of-flight",
author = "Moyer, {Susanne C.} and Marzilli, {Lisa A.} and Woods, {Amina S.} and Laiko, {Victor V.} and Doroshenko, {Vladimir M.} and Cotter, {Robert J.}",
year = "2003",
month = "3",
day = "15",
doi = "10.1016/S1387-3806(02)00972-7",
language = "English (US)",
volume = "226",
pages = "133--150",
journal = "International Journal of Mass Spectrometry",
issn = "1387-3806",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI) on a quadrupole ion trap mass spectrometer

AU - Moyer, Susanne C.

AU - Marzilli, Lisa A.

AU - Woods, Amina S.

AU - Laiko, Victor V.

AU - Doroshenko, Vladimir M.

AU - Cotter, Robert J.

PY - 2003/3/15

Y1 - 2003/3/15

N2 - A new atmospheric pressure ionization technique, atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI), was recently introduced by Laiko et al. [U.S. Patent 5,965,884; Abstracts of the 4th International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, 25-29 August 1998; Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, TX, 1999; Anal. Chem. 72 (2000) 652]. This source has been coupled to an orthogonal time-of-flight mass spectrometer [U.S. Patent 5,965,884; Abstracts of the 4th International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, 25-29 August 1998; Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, TX, 1999; Anal. Chem. 72 (2000) 652] and to an ion trap mass spectrometer (ITMS) [Anal. Chem. 72 (2000) 5239; Atmospheric Pressure MALDI/Ion Trap Mass Spectrometry, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000; An Atmospheric Pressure MALDI Probe for Use with ESI Source Interfaces, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000; Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000]. Here, we present the current status of the work involving the development of an AP MALDI source for an ITMS. In addition, we present recent work from our own laboratory to demonstrate the utility of this novel configuration.

AB - A new atmospheric pressure ionization technique, atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI), was recently introduced by Laiko et al. [U.S. Patent 5,965,884; Abstracts of the 4th International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, 25-29 August 1998; Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, TX, 1999; Anal. Chem. 72 (2000) 652]. This source has been coupled to an orthogonal time-of-flight mass spectrometer [U.S. Patent 5,965,884; Abstracts of the 4th International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, 25-29 August 1998; Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, TX, 1999; Anal. Chem. 72 (2000) 652] and to an ion trap mass spectrometer (ITMS) [Anal. Chem. 72 (2000) 5239; Atmospheric Pressure MALDI/Ion Trap Mass Spectrometry, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000; An Atmospheric Pressure MALDI Probe for Use with ESI Source Interfaces, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000; Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization, Proceedings of the 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, CA, June 2000]. Here, we present the current status of the work involving the development of an AP MALDI source for an ITMS. In addition, we present recent work from our own laboratory to demonstrate the utility of this novel configuration.

KW - Acetylation

KW - AP MALDI

KW - ITMS

KW - Oligosaccharides

KW - Phosphorylation

KW - Protein digests

KW - Proteins

KW - Sulfation

KW - Tandem mass spectrometry

KW - Time-of-flight

UR - http://www.scopus.com/inward/record.url?scp=0037445418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037445418&partnerID=8YFLogxK

U2 - 10.1016/S1387-3806(02)00972-7

DO - 10.1016/S1387-3806(02)00972-7

M3 - Article

AN - SCOPUS:0037445418

VL - 226

SP - 133

EP - 150

JO - International Journal of Mass Spectrometry

JF - International Journal of Mass Spectrometry

SN - 1387-3806

IS - 1

ER -