TY - JOUR
T1 - Atlas-based analysis of neurodevelopment from infancy to adulthood using diffusion tensor imaging and applications for automated abnormality detection
AU - Faria, Andreia V.
AU - Zhang, Jiangyang
AU - Oishi, Kenichi
AU - Li, Xin
AU - Jiang, Hangyi
AU - Akhter, Kazi
AU - Hermoye, Laurent
AU - Lee, Seung Koo
AU - Hoon, Alexander
AU - Stashinko, Elaine
AU - Miller, Michael I.
AU - van Zijl, Peter C.M.
AU - Mori, Susumu
N1 - Funding Information:
This publication was made possible by the grant number F05NS059230 (AVF) from the National Institute of Neurological Disorders and Stroke (NINDS) , a component of the National Institutes of Health (NIH) . This research was also supported by NIH grants P41 RR015241 , AG20012 and RR015241 (SM). Dr. Peter C.M. van Zijl is a paid lecturer for Philips Medical Systems. This arrangement has been approved by Johns Hopkins University in accordance with its conflict of interest policies.
PY - 2010/8
Y1 - 2010/8
N2 - Quantification of normal brain maturation is a crucial step in understanding developmental abnormalities in brain anatomy and function. The aim of this study was to develop atlas-based tools for time-dependent quantitative image analysis, and to characterize the anatomical changes that occur from 2. years of age to adulthood. We used large deformation diffeomorphic metric mapping to register diffusion tensor images of normal participants into the common coordinates and used a pre-segmented atlas to segment the entire brain into 176 structures. Both voxel- and atlas-based analyses reported a structure that showed distinctive changes in terms of its volume and diffusivity measures. In the white matter, fractional anisotropy (FA) linearly increased with age in logarithmic scale, while diffusivity indices, such as apparent diffusion coefficient (ADC), and axial and radial diffusivity, decreased at a different rate in several regions. The average, variability, and the time course of each measured parameter are incorporated into the atlas, which can be used for automated detection of developmental abnormalities. As a demonstration of future application studies, the brainstem anatomy of cerebral palsy patients was evaluated and the altered anatomy was delineated.
AB - Quantification of normal brain maturation is a crucial step in understanding developmental abnormalities in brain anatomy and function. The aim of this study was to develop atlas-based tools for time-dependent quantitative image analysis, and to characterize the anatomical changes that occur from 2. years of age to adulthood. We used large deformation diffeomorphic metric mapping to register diffusion tensor images of normal participants into the common coordinates and used a pre-segmented atlas to segment the entire brain into 176 structures. Both voxel- and atlas-based analyses reported a structure that showed distinctive changes in terms of its volume and diffusivity measures. In the white matter, fractional anisotropy (FA) linearly increased with age in logarithmic scale, while diffusivity indices, such as apparent diffusion coefficient (ADC), and axial and radial diffusivity, decreased at a different rate in several regions. The average, variability, and the time course of each measured parameter are incorporated into the atlas, which can be used for automated detection of developmental abnormalities. As a demonstration of future application studies, the brainstem anatomy of cerebral palsy patients was evaluated and the altered anatomy was delineated.
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U2 - 10.1016/j.neuroimage.2010.04.238
DO - 10.1016/j.neuroimage.2010.04.238
M3 - Article
C2 - 20420929
AN - SCOPUS:77953694885
SN - 1053-8119
VL - 52
SP - 415
EP - 428
JO - NeuroImage
JF - NeuroImage
IS - 2
ER -