Asynchrony of lingual muscle recruitment during sleep in obstructive sleep apnea

Yaniv Dotan, Giora Pillar, Alan R Schwartz, Arie Oliven

Research output: Contribution to journalArticle

Abstract

Pharyngeal collapsibility during sleep increases primarily due to decline in dilator muscle activity. However, genioglossus EMG is known to increase during apneas and hypopneas, usually without reversing upper airway obstruction or inspiratory flow limitation. The present study was undertaken to test the hypothesis that intense activation of the genioglossus fails to prevent pharyngeal obstruction during sleep, and to evaluate if sleep-induced changes in tongue muscle coordination may be responsible for this phenomenon. We compared genioglossus and tongue retractors EMG activity in 13 obstructive sleep apnea (OSA) patients during wakefulness, while breathing through inspiratory resistors, to the activity observed at the end of apneas and hypopneas after 25 mg of brotizolam, before arousal, at equal esophageal pressure. During wakefulness, resistive breathing triggered increases in both genioglossus and retractor EMG. Activation of agonist tongue muscles differed considerably from that of the arm, as both genioglossus and retractors were activated similarly during all tongue movements. During sleep, flow limitation triggered increases in genioglossal EMG that could reach more than twofold the level observed while awake. In contrast, EMGs of the retractors reached less than half the wakefulness level. In sleeping OSA patients, genioglossal activity may increase during obstructed breathing to levels that exceed substantially those required to prevent pharyngeal collapse during wakefulness. In contrast, coactivation of retractors is deficient during sleep. These findings suggest that sleep-induced alteration in tongue muscle coordination may be responsible for the failure of high genioglossal EMG activity to alleviate flow limitation.

Original languageEnglish (US)
Pages (from-to)1516-1524
Number of pages9
JournalJournal of Applied Physiology
Volume118
Issue number12
DOIs
StatePublished - Jun 15 2015

Fingerprint

Obstructive Sleep Apnea
Tongue
Sleep
Wakefulness
Muscles
Respiration
brotizolam
Apnea
Airway Obstruction
Arousal
Arm
Pressure

Keywords

  • Control of breathing
  • Genioglossus
  • Obstructive sleep apnea
  • Tongue retractors
  • Upper airway

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Asynchrony of lingual muscle recruitment during sleep in obstructive sleep apnea. / Dotan, Yaniv; Pillar, Giora; Schwartz, Alan R; Oliven, Arie.

In: Journal of Applied Physiology, Vol. 118, No. 12, 15.06.2015, p. 1516-1524.

Research output: Contribution to journalArticle

Dotan, Yaniv ; Pillar, Giora ; Schwartz, Alan R ; Oliven, Arie. / Asynchrony of lingual muscle recruitment during sleep in obstructive sleep apnea. In: Journal of Applied Physiology. 2015 ; Vol. 118, No. 12. pp. 1516-1524.
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