Asymptomatic non-ulcerative genital tract infections in a rural Ugandan population

L. A. Paxton, N. Sewankambo, Ronald H Gray, D. Serwadda, D. McNairn, C. Li, Maria J Wawer

Research output: Contribution to journalArticle

Abstract

Objective: To document the prevalence of asymptomatic non-ulcerative genital tract infections (GTI) in a rural African cohort. Methods: The study population consisted of all adults aged 15-59 residing in 56 rural communities of Rakai District, southwest Uganda, enrolled in the Rakai STD Control for AIDS Prevention Study. Participants were interviewed about the occurrence of vaginal or urethral discharge and frequent or painful urination in the previous 6 months. Respondents were asked to provide blood and a first catch urine sample. Serum was tested for HIV-1. Urine was tested with ligase chain reaction (LCR) for N gonorrhoeae and C trachomatis. Women provided two self administered vaginal swabs; one for T vaginalis culture and the other for a Gram stained slide for bacterial vaginosis (BV) diagnosis. Results: A total of 12 827 men and women were enrolled. Among 5140 men providing specimens, 0.9% had gonorrhoea and 2.1% had chlamydia. Among 6356 women, 1.5 % had gonorrhoea, 2.4% had chlamydia, 23.8% were infected with trichomonas and 50.9% had BV. 53% of men and 66% of women with gonorrhoea did not report genital discharge or dysuria at anytime within the previous 6 months. 92% of men and 76% of women with chlamydia and over 80% of women with trichomonas or BV were asymptomatic. The sensitivities of dysuria or urethral discharge for detection of infection with either gonorrhoea or chlamydia among men were only 21.4% and 9.8% respectively; similarly, among women the sensitivity of dysuria was 21.0% while that of vaginal discharge was 11.6%. For trichomonas or BV the sensitivity of dysuria was 11.7% and that of vaginal discharge was 10.5%. Conclusion: The prevalence of non-ulcerative GTIs is very high in this rural African population and the majority are asymptomatic. Reliance on reported symptoms alone would have missed 80% of men and 72% of women with either gonorrhoea or chlamydia, and over 80% of women with trichomonas or BV. To achieve STD control in this and similar populations public health programmes must target asymptomatic infections.

Original languageEnglish (US)
Pages (from-to)421-425
Number of pages5
JournalSexually Transmitted Infections
Volume74
Issue number6
StatePublished - 1998
Externally publishedYes

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Reproductive Tract Infections
Rural Population
Gonorrhea
Bacterial Vaginosis
Chlamydia
Trichomonas
Dysuria
Vaginal Discharge
Sexually Transmitted Diseases
Ligase Chain Reaction
Urine
Asymptomatic Infections
Uganda
Urination
Population
HIV-1
Acquired Immunodeficiency Syndrome
Public Health

Keywords

  • Chlamydia
  • Gonorrhoea
  • STDs
  • Trichomonas
  • Uganda

ASJC Scopus subject areas

  • Dermatology
  • Microbiology (medical)
  • Immunology

Cite this

Asymptomatic non-ulcerative genital tract infections in a rural Ugandan population. / Paxton, L. A.; Sewankambo, N.; Gray, Ronald H; Serwadda, D.; McNairn, D.; Li, C.; Wawer, Maria J.

In: Sexually Transmitted Infections, Vol. 74, No. 6, 1998, p. 421-425.

Research output: Contribution to journalArticle

Paxton, LA, Sewankambo, N, Gray, RH, Serwadda, D, McNairn, D, Li, C & Wawer, MJ 1998, 'Asymptomatic non-ulcerative genital tract infections in a rural Ugandan population', Sexually Transmitted Infections, vol. 74, no. 6, pp. 421-425.
Paxton LA, Sewankambo N, Gray RH, Serwadda D, McNairn D, Li C et al. Asymptomatic non-ulcerative genital tract infections in a rural Ugandan population. Sexually Transmitted Infections. 1998;74(6):421-425.
Paxton, L. A. ; Sewankambo, N. ; Gray, Ronald H ; Serwadda, D. ; McNairn, D. ; Li, C. ; Wawer, Maria J. / Asymptomatic non-ulcerative genital tract infections in a rural Ugandan population. In: Sexually Transmitted Infections. 1998 ; Vol. 74, No. 6. pp. 421-425.
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abstract = "Objective: To document the prevalence of asymptomatic non-ulcerative genital tract infections (GTI) in a rural African cohort. Methods: The study population consisted of all adults aged 15-59 residing in 56 rural communities of Rakai District, southwest Uganda, enrolled in the Rakai STD Control for AIDS Prevention Study. Participants were interviewed about the occurrence of vaginal or urethral discharge and frequent or painful urination in the previous 6 months. Respondents were asked to provide blood and a first catch urine sample. Serum was tested for HIV-1. Urine was tested with ligase chain reaction (LCR) for N gonorrhoeae and C trachomatis. Women provided two self administered vaginal swabs; one for T vaginalis culture and the other for a Gram stained slide for bacterial vaginosis (BV) diagnosis. Results: A total of 12 827 men and women were enrolled. Among 5140 men providing specimens, 0.9{\%} had gonorrhoea and 2.1{\%} had chlamydia. Among 6356 women, 1.5 {\%} had gonorrhoea, 2.4{\%} had chlamydia, 23.8{\%} were infected with trichomonas and 50.9{\%} had BV. 53{\%} of men and 66{\%} of women with gonorrhoea did not report genital discharge or dysuria at anytime within the previous 6 months. 92{\%} of men and 76{\%} of women with chlamydia and over 80{\%} of women with trichomonas or BV were asymptomatic. The sensitivities of dysuria or urethral discharge for detection of infection with either gonorrhoea or chlamydia among men were only 21.4{\%} and 9.8{\%} respectively; similarly, among women the sensitivity of dysuria was 21.0{\%} while that of vaginal discharge was 11.6{\%}. For trichomonas or BV the sensitivity of dysuria was 11.7{\%} and that of vaginal discharge was 10.5{\%}. Conclusion: The prevalence of non-ulcerative GTIs is very high in this rural African population and the majority are asymptomatic. Reliance on reported symptoms alone would have missed 80{\%} of men and 72{\%} of women with either gonorrhoea or chlamydia, and over 80{\%} of women with trichomonas or BV. To achieve STD control in this and similar populations public health programmes must target asymptomatic infections.",
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AU - Li, C.

AU - Wawer, Maria J

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N2 - Objective: To document the prevalence of asymptomatic non-ulcerative genital tract infections (GTI) in a rural African cohort. Methods: The study population consisted of all adults aged 15-59 residing in 56 rural communities of Rakai District, southwest Uganda, enrolled in the Rakai STD Control for AIDS Prevention Study. Participants were interviewed about the occurrence of vaginal or urethral discharge and frequent or painful urination in the previous 6 months. Respondents were asked to provide blood and a first catch urine sample. Serum was tested for HIV-1. Urine was tested with ligase chain reaction (LCR) for N gonorrhoeae and C trachomatis. Women provided two self administered vaginal swabs; one for T vaginalis culture and the other for a Gram stained slide for bacterial vaginosis (BV) diagnosis. Results: A total of 12 827 men and women were enrolled. Among 5140 men providing specimens, 0.9% had gonorrhoea and 2.1% had chlamydia. Among 6356 women, 1.5 % had gonorrhoea, 2.4% had chlamydia, 23.8% were infected with trichomonas and 50.9% had BV. 53% of men and 66% of women with gonorrhoea did not report genital discharge or dysuria at anytime within the previous 6 months. 92% of men and 76% of women with chlamydia and over 80% of women with trichomonas or BV were asymptomatic. The sensitivities of dysuria or urethral discharge for detection of infection with either gonorrhoea or chlamydia among men were only 21.4% and 9.8% respectively; similarly, among women the sensitivity of dysuria was 21.0% while that of vaginal discharge was 11.6%. For trichomonas or BV the sensitivity of dysuria was 11.7% and that of vaginal discharge was 10.5%. Conclusion: The prevalence of non-ulcerative GTIs is very high in this rural African population and the majority are asymptomatic. Reliance on reported symptoms alone would have missed 80% of men and 72% of women with either gonorrhoea or chlamydia, and over 80% of women with trichomonas or BV. To achieve STD control in this and similar populations public health programmes must target asymptomatic infections.

AB - Objective: To document the prevalence of asymptomatic non-ulcerative genital tract infections (GTI) in a rural African cohort. Methods: The study population consisted of all adults aged 15-59 residing in 56 rural communities of Rakai District, southwest Uganda, enrolled in the Rakai STD Control for AIDS Prevention Study. Participants were interviewed about the occurrence of vaginal or urethral discharge and frequent or painful urination in the previous 6 months. Respondents were asked to provide blood and a first catch urine sample. Serum was tested for HIV-1. Urine was tested with ligase chain reaction (LCR) for N gonorrhoeae and C trachomatis. Women provided two self administered vaginal swabs; one for T vaginalis culture and the other for a Gram stained slide for bacterial vaginosis (BV) diagnosis. Results: A total of 12 827 men and women were enrolled. Among 5140 men providing specimens, 0.9% had gonorrhoea and 2.1% had chlamydia. Among 6356 women, 1.5 % had gonorrhoea, 2.4% had chlamydia, 23.8% were infected with trichomonas and 50.9% had BV. 53% of men and 66% of women with gonorrhoea did not report genital discharge or dysuria at anytime within the previous 6 months. 92% of men and 76% of women with chlamydia and over 80% of women with trichomonas or BV were asymptomatic. The sensitivities of dysuria or urethral discharge for detection of infection with either gonorrhoea or chlamydia among men were only 21.4% and 9.8% respectively; similarly, among women the sensitivity of dysuria was 21.0% while that of vaginal discharge was 11.6%. For trichomonas or BV the sensitivity of dysuria was 11.7% and that of vaginal discharge was 10.5%. Conclusion: The prevalence of non-ulcerative GTIs is very high in this rural African population and the majority are asymptomatic. Reliance on reported symptoms alone would have missed 80% of men and 72% of women with either gonorrhoea or chlamydia, and over 80% of women with trichomonas or BV. To achieve STD control in this and similar populations public health programmes must target asymptomatic infections.

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KW - Gonorrhoea

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