Asymptomatic conjunctival mucosa-associated lymphoid tissue-type lymphoma with presumed intraocular involvement

Pradeep Ramulu, Nicholas T. Iliff, W. Richard Green, Irene C. Kuo

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To report a case of conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma with presumed intraocular involvement. METHODS: Observational case report. RESULTS: A 73-year-old white man presented for a routine eye examination and was found to have a salmon-colored bulbar conjunctival mass of the left eye. Ultrasound showed a low-reflective mass with diffuse thickening of the ciliary body and choroid. Immunohistochemistry and flow cytometry of an incisional biopsy specimen suggested a polyclonal lesion. Treatment with topical steroids yielded no clinical improvement, and excisional biopsy was performed. A diagnosis of MALT lymphoma was made after polymerase chain reaction (PCR) analysis of the immunoglobulin heavy chain (IgH) locus revealed a clonal B-cell population. CONCLUSIONS: Conjunctival MALT lymphoma can present without symptoms and can extend intraocularly. PCR analysis of the IgH locus can identify lesion clonality when immunohistochemistry and flow cytometry fail to do so.

Original languageEnglish (US)
Pages (from-to)484-486
Number of pages3
JournalCornea
Volume26
Issue number4
DOIs
StatePublished - May 2007

Keywords

  • Conjunctiva
  • Lymphoid hyperplasia
  • Lymphoma
  • Mucosaassociated lymphoid tissue

ASJC Scopus subject areas

  • Ophthalmology

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