Asymptomatic aneurysm of the cavernous and supraclinoid internal carotid artery in a patient with Balamuthia mandrillaris encephalitis

Ludwig D. Orozco, Majid A. Khan, Jonathan D. Fratkin, William C. Hanigan

Research output: Contribution to journalArticle

Abstract

This is the first report to our knowledge of the successful treatment of an asymptomatic mycotic aneurysm associated with Balamuthia mandrillaris encephalitis. A 27-year-old male with end-stage renal disease presented with generalized seizures following renal transplantation. MRI demonstrated multiple brain masses and an aneurysm of the cavernous and supraclinoid carotid artery. Autopsy of the donor's brain revealed Balamuthia encephalitis. The patient was placed on an anti-amebic regimen, his condition improved, and 126 days after the kidney transplant, MRI brain showed resolution of the aneurysm and improvement of the enhancing lesions. Balamuthia mandrillaris has been shown to cause a granulomatous encephalitis, with prominent vasculitis. This is the first report to demonstrate the risk of aneurysm formation associated with this infection. Prolonged anti-amebic treatment resulted in resolution of the aneurysm without clinical evidence of subarachnoid hemorrhage.

Original languageEnglish (US)
Pages (from-to)1118-1120
Number of pages3
JournalJournal of Clinical Neuroscience
Volume18
Issue number8
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • Balamuthia mandrillaris encephalitis
  • Mycotic aneurysm
  • Renal transplantation

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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