Abstract
Hinge et al. show that mitochondria are permanently remodeled after HSC division despite re-entry into quiescence. HSCs keep dysfunctional mitochondria through asymmetric segregation during mitosis, which does not prevent reversible HSC quiescence and cell cycle progression but drives their functional decline via asynchrony in the cell cycle and biosynthetic gene expression.
Original language | English (US) |
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Pages (from-to) | 420-430.e6 |
Journal | Cell stem cell |
Volume | 26 |
Issue number | 3 |
DOIs | |
State | Published - Mar 5 2020 |
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Cell Biology