Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

Ashwini Hinge, Jingyi He, James Bartram, Jose Javier, Juying Xu, Ellen Fjellman, Hiromi Sesaki, Tingyu Li, Jie Yu, Mark Wunderlich, James Mulloy, Matthew Kofron, Nathan Salomonis, H. Leighton Grimes, Marie Dominique Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

Hinge et al. show that mitochondria are permanently remodeled after HSC division despite re-entry into quiescence. HSCs keep dysfunctional mitochondria through asymmetric segregation during mitosis, which does not prevent reversible HSC quiescence and cell cycle progression but drives their functional decline via asynchrony in the cell cycle and biosynthetic gene expression.

Original languageEnglish (US)
Pages (from-to)420-430.e6
JournalCell stem cell
Volume26
Issue number3
DOIs
StatePublished - Mar 5 2020

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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