Asymmetrical effect of unilateral cortical lesions and amphetamine on DRL-20: A time-loss analysis

Kenneth L. Kubos, Joseph V. Brady, Timothy H Moran, Curtis H. Smith, Robert G. Robinson

Research output: Contribution to journalArticle

Abstract

Male Sprague Dawley rats received unilateral 1.5 mm diameter focal suction lesions of either the left or right orbito-frontal cortex and were tested for response to 6 doses of amphetamine sulfate ranging from 0.5 to 1.5 mg/kg on a DRL-20 schedule of reinforcement. Right hemispheric lesion animals obtained a greater number of control reinforcements and were more sensitive to amphetamine's disruptive effects, showing a greater dose-related decrease in water rewards obtained than left lesion animals. An analysis method is introduced which combines the interactive effects of premature responses and their IRT value in a way that relates directly to reinforcement attainment. Calculated total session time made unavailable for reinforcement due to premature responding, correlated negatively (r=-.942) with the number of reinforcements obtained.

Original languageEnglish (US)
Pages (from-to)1001-1006
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume22
Issue number6
DOIs
StatePublished - 1985

Fingerprint

Amphetamine
Reinforcement
Animals
Reinforcement Schedule
Suction
Frontal Lobe
Reward
Sprague Dawley Rats
Rats
Reinforcement (Psychology)
Water

Keywords

  • Accumbens Reinforcement omission
  • Amphetamine
  • Cortical lesion
  • DRL-20
  • Laterality
  • Supersensitivity

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Asymmetrical effect of unilateral cortical lesions and amphetamine on DRL-20 : A time-loss analysis. / Kubos, Kenneth L.; Brady, Joseph V.; Moran, Timothy H; Smith, Curtis H.; Robinson, Robert G.

In: Pharmacology Biochemistry and Behavior, Vol. 22, No. 6, 1985, p. 1001-1006.

Research output: Contribution to journalArticle

Kubos, Kenneth L. ; Brady, Joseph V. ; Moran, Timothy H ; Smith, Curtis H. ; Robinson, Robert G. / Asymmetrical effect of unilateral cortical lesions and amphetamine on DRL-20 : A time-loss analysis. In: Pharmacology Biochemistry and Behavior. 1985 ; Vol. 22, No. 6. pp. 1001-1006.
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