Asymmetrical effect of unilateral cortical lesions and amphetamine on DRL-20: A time-loss analysis

Kenneth L. Kubos, Joseph V. Brady, Timothy H. Moran, Curtis H. Smith, Robert G. Robinson

Research output: Contribution to journalArticlepeer-review

Abstract

Male Sprague Dawley rats received unilateral 1.5 mm diameter focal suction lesions of either the left or right orbito-frontal cortex and were tested for response to 6 doses of amphetamine sulfate ranging from 0.5 to 1.5 mg/kg on a DRL-20 schedule of reinforcement. Right hemispheric lesion animals obtained a greater number of control reinforcements and were more sensitive to amphetamine's disruptive effects, showing a greater dose-related decrease in water rewards obtained than left lesion animals. An analysis method is introduced which combines the interactive effects of premature responses and their IRT value in a way that relates directly to reinforcement attainment. Calculated total session time made unavailable for reinforcement due to premature responding, correlated negatively (r=-.942) with the number of reinforcements obtained.

Original languageEnglish (US)
Pages (from-to)1001-1006
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume22
Issue number6
DOIs
StatePublished - Jun 1985

Keywords

  • Accumbens Reinforcement omission
  • Amphetamine
  • Cortical lesion
  • DRL-20
  • Laterality
  • Supersensitivity

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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