Asymmetrical changes in ventricular wall mass by asynchronous electrical activation of the heart

F. W. Prinzen, T. Delhaas, T. Arts, R. S. Reneman, E. Yellin, H. Halperin, J. Janicki, E. Hoffmam, K. Tsujioka

Research output: Contribution to journalArticle

Abstract

Ventricular pacing causes asynchronous electrical activation of the ventricular wall, because impulse conduction occurs via muscle fibers rather than via the Purkinje system. Chronic (up to 3 months) ventricular pacing caused about 30% decrease of wall mass in early activated regions but did not change wall mass in late activated regions. These are the first data indicating that chronic asynchronous activation induces asymmetrical structural adaptations. This asymmetry is likely to be evoked by regional differences in contractile work, as demonstrated in previous experiments from our laboratory. The nature of the structural adaptation as well as its clinical implications deserve more detailed investigation.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalAdvances in experimental medicine and biology
Volume346
StatePublished - Dec 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Prinzen, F. W., Delhaas, T., Arts, T., Reneman, R. S., Yellin, E., Halperin, H., Janicki, J., Hoffmam, E., & Tsujioka, K. (1993). Asymmetrical changes in ventricular wall mass by asynchronous electrical activation of the heart. Advances in experimental medicine and biology, 346, 257-264.