Asymmetric large for gestational age newborns in pregnancies complicated by diabetes mellitus: Is maternal obesity a culprit?

Maisa N. Feghali, Jane C. Khoury, Julia Timofeev, David Shveiky, Rita W. Driggers, Menachem Miodovnik

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Evaluate the association between body mass index (BMI) and the delivery of an asymmetrically large for gestational age (A-LGA) newborn in women with diabetes. Methods: Retrospective analysis of 306 pregnancies complicated by Type 1 and 55 by Type 2 diabetes. Results: The prevalence of Type 1 and Type 2 diabetics delivering large for gestational age (LGA) infants was 42% and 49%, respectively. Of these 49% and 55% were A-LGA, respectively. Pre-pregnancy BMI was not associated with increased odds of delivering an A-LGA newborn in women with Type 1 or 2 diabetes. However, in Type 1 diabetics, each one-pound increase in maternal weight during pregnancy resulted in 4% increased odds of delivering an A-LGA newborn. For Type 2 diabetics, the odds of delivering an A-LGA infant was decreased by 10% for each 0.1 unit/kg increase in insulin dose. Conclusion: Although there is a known association between obesity and LGA in women with diabetes, we found that overweight and obese women with Type 1 or Type 2 diabetes do not have increased odds of delivering an A-LGA newborn. However, insulin dose in Type 2 diabetes and maternal weight gain in Type 1 diabetes were significantly associated with the odds of delivering an A-LGA neonate.

Original languageEnglish (US)
Pages (from-to)32-35
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume25
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • LGA
  • overweight
  • type 1 diabetes
  • type 2 diabetes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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