TY - JOUR
T1 - Asymmetric dimethylarginine predicts survival in the elderly
AU - Pizzarelli, Francesco
AU - Maas, Renke
AU - Dattolo, Pietro
AU - Tripepi, Giovanni
AU - Michelassi, Stefano
AU - D'Arrigo, Graziella
AU - Mieth, Maren
AU - Bandinelli, Stefania
AU - Ferrucci, Luigi
AU - Zoccali, Carmine
PY - 2013/12
Y1 - 2013/12
N2 - Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase implicated in several age-related biological mechanisms such as telomere shortening and cell senescence. We tested the hypothesis that ADMA blood level is an independent predictor of mortality in elderly. This is a longitudinal population-based cohort study. Participants are a representative cohort of 1,025 men and women (age range 65-102 years) living in Chianti area, Tuscany, Italy. The plasma ADMA was measured by liquid chromatography- tandem mass spectrometry. During the follow-up (95±32 months), 384 individuals died, of whom 141 (37 %) died of cardiovascular (CV) causes. In adjusted analyses, the plasma ADMAwas the strongest predictor of all-cause mortality (HR (0.1 μMol/L) 1.26, 95 % CI 1.10-1.44, P60 μMol/L. Notwithstanding the association ofADMA with all-cause mortality was robust, this biomarker failed to add predictive power to a simple model based on the risk factors in the elderly (area under the ROC curve 0.85±0.01 vs. 0.84±0.01). ADMA is a strong independent predictor of mortality in the older population, and L-arginine modifies the effect of ADMA on survival. The mechanisms for this association should be targeted by future studies.
AB - Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase implicated in several age-related biological mechanisms such as telomere shortening and cell senescence. We tested the hypothesis that ADMA blood level is an independent predictor of mortality in elderly. This is a longitudinal population-based cohort study. Participants are a representative cohort of 1,025 men and women (age range 65-102 years) living in Chianti area, Tuscany, Italy. The plasma ADMA was measured by liquid chromatography- tandem mass spectrometry. During the follow-up (95±32 months), 384 individuals died, of whom 141 (37 %) died of cardiovascular (CV) causes. In adjusted analyses, the plasma ADMAwas the strongest predictor of all-cause mortality (HR (0.1 μMol/L) 1.26, 95 % CI 1.10-1.44, P60 μMol/L. Notwithstanding the association ofADMA with all-cause mortality was robust, this biomarker failed to add predictive power to a simple model based on the risk factors in the elderly (area under the ROC curve 0.85±0.01 vs. 0.84±0.01). ADMA is a strong independent predictor of mortality in the older population, and L-arginine modifies the effect of ADMA on survival. The mechanisms for this association should be targeted by future studies.
KW - ADMA
KW - Cardiovascular risk factor
KW - Elderly
KW - Population study
KW - Survival
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U2 - 10.1007/s11357-013-9523-1
DO - 10.1007/s11357-013-9523-1
M3 - Article
C2 - 23584888
AN - SCOPUS:84890038945
SN - 0161-9152
VL - 35
SP - 2465
EP - 2475
JO - Age
JF - Age
IS - 6
ER -