Astroglia induce neurogenesis from adult neural stem cells

Hongjun Song, Charles F. Stevens, Fred H. Gage

Research output: Contribution to journalArticle

Abstract

During an investigation of the mechanisms through which the local environment controls the fate specification of adult neural stem cells, we discovered that adult astrocytes from hippocampus are capable of regulating neurogenesis by instructing the stem cells to adopt a neuronal fate. This role in fate specification was unexpected because, during development, neurons are generated before most of the astrocytes. Our findings, together with recent reports that astrocytes regulate synapse formation and synaptic transmission, reinforce the emerging view that astrocytes have an active regulatory role-rather than merely supportive roles traditionally assigned to them-in the mature central nervous system.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalNature
Volume417
Issue number6884
DOIs
StatePublished - May 2 2002
Externally publishedYes

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Adult Stem Cells
Neural Stem Cells
Neurogenesis
Astrocytes
Synaptic Transmission
Synapses
Hippocampus
Stem Cells
Central Nervous System
Neurons

ASJC Scopus subject areas

  • General

Cite this

Song, H., Stevens, C. F., & Gage, F. H. (2002). Astroglia induce neurogenesis from adult neural stem cells. Nature, 417(6884), 39-44. https://doi.org/10.1038/417039a

Astroglia induce neurogenesis from adult neural stem cells. / Song, Hongjun; Stevens, Charles F.; Gage, Fred H.

In: Nature, Vol. 417, No. 6884, 02.05.2002, p. 39-44.

Research output: Contribution to journalArticle

Song, H, Stevens, CF & Gage, FH 2002, 'Astroglia induce neurogenesis from adult neural stem cells', Nature, vol. 417, no. 6884, pp. 39-44. https://doi.org/10.1038/417039a
Song, Hongjun ; Stevens, Charles F. ; Gage, Fred H. / Astroglia induce neurogenesis from adult neural stem cells. In: Nature. 2002 ; Vol. 417, No. 6884. pp. 39-44.
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