Asthma outcomes

Pulmonary physiology

Robert S. Tepper, Robert A Wise, Ronina Covar, Charles G. Irvin, Carolyn M. Kercsmar, Monica Kraft, Mark Chang Hwa Liu, George T. O'Connor, Stephen P. Peters, Ronald Sorkness, Alkis Togias

Research output: Contribution to journalArticle

Abstract

Background: Outcomes of pulmonary physiology have a central place in asthma clinical research. Objective: At the request of National Institutes of Health (NIH) institutes and other federal agencies, an expert group was convened to provide recommendations on the use of pulmonary function measures as asthma outcomes that should be assessed in a standardized fashion in future asthma clinical trials and studies to allow for cross-study comparisons. Methods: Our subcommittee conducted a comprehensive search of PubMed to identify studies that focused on the validation of various airway response tests used in asthma clinical research. The subcommittee classified the instruments as core (to be required in future studies), supplemental (to be used according to study aims and in a standardized fashion), or emerging (requiring validation and standardization). This work was discussed at an NIH-organized workshop in March 2010 and finalized in September 2011. Results: A list of pulmonary physiology outcomes that applies to both adults and children older than 6 years was created. These outcomes were then categorized into core, supplemental, and emerging. Spirometric outcomes (FEV 1, forced vital capacity, and FEV 1/forced vital capacity ratio) are proposed as core outcomes for study population characterization, for observational studies, and for prospective clinical trials. Bronchodilator reversibility and prebronchodilator and postbronchodilator FEV 1 also are core outcomes for study population characterization and observational studies. Conclusions: The subcommittee considers pulmonary physiology outcomes of central importance in asthma and proposes spirometric outcomes as core outcomes for all future NIH-initiated asthma clinical research.

Original languageEnglish (US)
JournalThe Journal of Allergy and Clinical Immunology
Volume129
Issue number3 SUPPL.
DOIs
StatePublished - Mar 2012

Fingerprint

Asthma
Lung
National Institutes of Health (U.S.)
Vital Capacity
Observational Studies
Research
Outcome Assessment (Health Care)
Clinical Trials
Bronchodilator Agents
PubMed
Population
Education

Keywords

  • airway responsiveness
  • gas exchange
  • lung volumes
  • peak expiratory flow monitoring
  • Spirometry

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Tepper, R. S., Wise, R. A., Covar, R., Irvin, C. G., Kercsmar, C. M., Kraft, M., ... Togias, A. (2012). Asthma outcomes: Pulmonary physiology. The Journal of Allergy and Clinical Immunology, 129(3 SUPPL.). https://doi.org/10.1016/j.jaci.2011.12.986

Asthma outcomes : Pulmonary physiology. / Tepper, Robert S.; Wise, Robert A; Covar, Ronina; Irvin, Charles G.; Kercsmar, Carolyn M.; Kraft, Monica; Liu, Mark Chang Hwa; O'Connor, George T.; Peters, Stephen P.; Sorkness, Ronald; Togias, Alkis.

In: The Journal of Allergy and Clinical Immunology, Vol. 129, No. 3 SUPPL., 03.2012.

Research output: Contribution to journalArticle

Tepper, RS, Wise, RA, Covar, R, Irvin, CG, Kercsmar, CM, Kraft, M, Liu, MCH, O'Connor, GT, Peters, SP, Sorkness, R & Togias, A 2012, 'Asthma outcomes: Pulmonary physiology', The Journal of Allergy and Clinical Immunology, vol. 129, no. 3 SUPPL.. https://doi.org/10.1016/j.jaci.2011.12.986
Tepper, Robert S. ; Wise, Robert A ; Covar, Ronina ; Irvin, Charles G. ; Kercsmar, Carolyn M. ; Kraft, Monica ; Liu, Mark Chang Hwa ; O'Connor, George T. ; Peters, Stephen P. ; Sorkness, Ronald ; Togias, Alkis. / Asthma outcomes : Pulmonary physiology. In: The Journal of Allergy and Clinical Immunology. 2012 ; Vol. 129, No. 3 SUPPL.
@article{eec06748f4ee458ba12988038895b550,
title = "Asthma outcomes: Pulmonary physiology",
abstract = "Background: Outcomes of pulmonary physiology have a central place in asthma clinical research. Objective: At the request of National Institutes of Health (NIH) institutes and other federal agencies, an expert group was convened to provide recommendations on the use of pulmonary function measures as asthma outcomes that should be assessed in a standardized fashion in future asthma clinical trials and studies to allow for cross-study comparisons. Methods: Our subcommittee conducted a comprehensive search of PubMed to identify studies that focused on the validation of various airway response tests used in asthma clinical research. The subcommittee classified the instruments as core (to be required in future studies), supplemental (to be used according to study aims and in a standardized fashion), or emerging (requiring validation and standardization). This work was discussed at an NIH-organized workshop in March 2010 and finalized in September 2011. Results: A list of pulmonary physiology outcomes that applies to both adults and children older than 6 years was created. These outcomes were then categorized into core, supplemental, and emerging. Spirometric outcomes (FEV 1, forced vital capacity, and FEV 1/forced vital capacity ratio) are proposed as core outcomes for study population characterization, for observational studies, and for prospective clinical trials. Bronchodilator reversibility and prebronchodilator and postbronchodilator FEV 1 also are core outcomes for study population characterization and observational studies. Conclusions: The subcommittee considers pulmonary physiology outcomes of central importance in asthma and proposes spirometric outcomes as core outcomes for all future NIH-initiated asthma clinical research.",
keywords = "airway responsiveness, gas exchange, lung volumes, peak expiratory flow monitoring, Spirometry",
author = "Tepper, {Robert S.} and Wise, {Robert A} and Ronina Covar and Irvin, {Charles G.} and Kercsmar, {Carolyn M.} and Monica Kraft and Liu, {Mark Chang Hwa} and O'Connor, {George T.} and Peters, {Stephen P.} and Ronald Sorkness and Alkis Togias",
year = "2012",
month = "3",
doi = "10.1016/j.jaci.2011.12.986",
language = "English (US)",
volume = "129",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "3 SUPPL.",

}

TY - JOUR

T1 - Asthma outcomes

T2 - Pulmonary physiology

AU - Tepper, Robert S.

AU - Wise, Robert A

AU - Covar, Ronina

AU - Irvin, Charles G.

AU - Kercsmar, Carolyn M.

AU - Kraft, Monica

AU - Liu, Mark Chang Hwa

AU - O'Connor, George T.

AU - Peters, Stephen P.

AU - Sorkness, Ronald

AU - Togias, Alkis

PY - 2012/3

Y1 - 2012/3

N2 - Background: Outcomes of pulmonary physiology have a central place in asthma clinical research. Objective: At the request of National Institutes of Health (NIH) institutes and other federal agencies, an expert group was convened to provide recommendations on the use of pulmonary function measures as asthma outcomes that should be assessed in a standardized fashion in future asthma clinical trials and studies to allow for cross-study comparisons. Methods: Our subcommittee conducted a comprehensive search of PubMed to identify studies that focused on the validation of various airway response tests used in asthma clinical research. The subcommittee classified the instruments as core (to be required in future studies), supplemental (to be used according to study aims and in a standardized fashion), or emerging (requiring validation and standardization). This work was discussed at an NIH-organized workshop in March 2010 and finalized in September 2011. Results: A list of pulmonary physiology outcomes that applies to both adults and children older than 6 years was created. These outcomes were then categorized into core, supplemental, and emerging. Spirometric outcomes (FEV 1, forced vital capacity, and FEV 1/forced vital capacity ratio) are proposed as core outcomes for study population characterization, for observational studies, and for prospective clinical trials. Bronchodilator reversibility and prebronchodilator and postbronchodilator FEV 1 also are core outcomes for study population characterization and observational studies. Conclusions: The subcommittee considers pulmonary physiology outcomes of central importance in asthma and proposes spirometric outcomes as core outcomes for all future NIH-initiated asthma clinical research.

AB - Background: Outcomes of pulmonary physiology have a central place in asthma clinical research. Objective: At the request of National Institutes of Health (NIH) institutes and other federal agencies, an expert group was convened to provide recommendations on the use of pulmonary function measures as asthma outcomes that should be assessed in a standardized fashion in future asthma clinical trials and studies to allow for cross-study comparisons. Methods: Our subcommittee conducted a comprehensive search of PubMed to identify studies that focused on the validation of various airway response tests used in asthma clinical research. The subcommittee classified the instruments as core (to be required in future studies), supplemental (to be used according to study aims and in a standardized fashion), or emerging (requiring validation and standardization). This work was discussed at an NIH-organized workshop in March 2010 and finalized in September 2011. Results: A list of pulmonary physiology outcomes that applies to both adults and children older than 6 years was created. These outcomes were then categorized into core, supplemental, and emerging. Spirometric outcomes (FEV 1, forced vital capacity, and FEV 1/forced vital capacity ratio) are proposed as core outcomes for study population characterization, for observational studies, and for prospective clinical trials. Bronchodilator reversibility and prebronchodilator and postbronchodilator FEV 1 also are core outcomes for study population characterization and observational studies. Conclusions: The subcommittee considers pulmonary physiology outcomes of central importance in asthma and proposes spirometric outcomes as core outcomes for all future NIH-initiated asthma clinical research.

KW - airway responsiveness

KW - gas exchange

KW - lung volumes

KW - peak expiratory flow monitoring

KW - Spirometry

UR - http://www.scopus.com/inward/record.url?scp=84857847940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857847940&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2011.12.986

DO - 10.1016/j.jaci.2011.12.986

M3 - Article

VL - 129

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 3 SUPPL.

ER -