Asthma in the elderly: A different disease?

Salvatore Battaglia, Alida Benfante, Mario Spatafora, Nicola Scichilone

Research output: Contribution to journalArticle

Abstract

Asthma is a chronic airway disease that affects all ages, but does this definition also include the elderly? Traditionally, asthma has been considered a disease of younger age, but epidemiological studies and clinical experience support the concept that asthma is as prevalent in older age as it is in the young. With the ever-increasing elderly population worldwide, the detection and proper management of the disease in old age may have a great impact from the public health perspective. Whether asthma in the elderly maintains the same characteristics as in young populations is an interesting matter. The diagnostic process in older individuals with suspected asthma follows the same steps, namely a detailed history supported by clinical examination and laboratory investigations; however, it should be recognised that elderly patients may partially lose reversibility of airway obstruction. The correct interpretation of spirometric curves in the elderly should take into account the physiological changes in the respiratory system. Several factors contribute to delaying the diagnosis of asthma in the elderly, including the age-related impairment in perception of breathlessness. The management of asthma in advanced age is complicated by the comorbidities and polypharmacotherapy, which advocate for a comprehensive approach with a multidimensional assessment. It should be emphasised that older age frequently represents an exclusion criterion for eligibility in clinical trials, and current asthma medications have rarely been tested in elderly asthmatics. Ageing is associated with pharmacokinetic changes of the medications. As a consequence, absorption, distribution, metabolism and excretion of antiasthmatic medications can be variably affected. Similarly, drug-to-drug interactions may reduce the effectiveness of inhaled medications and increase the risk of side-effects. For this reason, we propose the term “geriatric asthma” be preferred to the more generic “asthma in the elderly”.

Original languageEnglish (US)
Pages (from-to)18-28
Number of pages11
JournalBreathe
Volume12
Issue number1
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

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Asthma
Anti-Asthmatic Agents
Airway Obstruction
Disease Management
Drug Interactions
Geriatrics
Respiratory System
Dyspnea
Population
Comorbidity
Epidemiologic Studies
Chronic Disease
Pharmacokinetics
Public Health
History
Clinical Trials
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Battaglia, S., Benfante, A., Spatafora, M., & Scichilone, N. (2016). Asthma in the elderly: A different disease? Breathe, 12(1), 18-28. https://doi.org/10.1183/20734735.002816

Asthma in the elderly : A different disease? / Battaglia, Salvatore; Benfante, Alida; Spatafora, Mario; Scichilone, Nicola.

In: Breathe, Vol. 12, No. 1, 01.03.2016, p. 18-28.

Research output: Contribution to journalArticle

Battaglia, S, Benfante, A, Spatafora, M & Scichilone, N 2016, 'Asthma in the elderly: A different disease?', Breathe, vol. 12, no. 1, pp. 18-28. https://doi.org/10.1183/20734735.002816
Battaglia S, Benfante A, Spatafora M, Scichilone N. Asthma in the elderly: A different disease? Breathe. 2016 Mar 1;12(1):18-28. https://doi.org/10.1183/20734735.002816
Battaglia, Salvatore ; Benfante, Alida ; Spatafora, Mario ; Scichilone, Nicola. / Asthma in the elderly : A different disease?. In: Breathe. 2016 ; Vol. 12, No. 1. pp. 18-28.
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