Associations with health-related quality of life after intracerebral haemorrhage: Pooled analysis of INTERACT studies

Candice Delcourt, Danni Zheng, Xiaoying Chen, Maree Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Al-Shahi Salman, Mark Woodward, Yining Huang, Thompson Robinson, Pablo M. Lavados, Richard I. Lindley, Christian Stapf, Leo Davies, John Chalmers, Craig S. Anderson, Shoichiro Sato

Research output: Contribution to journalArticle

Abstract

Background and purpose Limited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH). We aimed to determine baseline factors associated with HRQoL among participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2). Methods The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated systolic BP (150-220 mm Hg). HRQoL was determined using the European Quality of Life Scale (EQ-5D) at 90 days, completed by patients or proxy responders. Binary logistic regression analyses were performed to identify factors associated with poor overall HRQoL. Results 2756 patients were included. Demographic, clinical and radiological factors associated with lower EQ-5D utility score were age, randomisation outside of China, antithrombotic use, high baseline National Institutes of Health Stroke Scale (NIHSS) score, larger ICH, presence of intraventricular extension and use of proxy responders. High (≥14) NIHSS score, larger ICH and proxy responders were associated with low scores in all five dimensions of the EQ-5D. The NIHSS score had a strong association with poor HRQoL (p<0.001). Female gender and antithrombotic use were associated with decreased scores in dimensions of pain/discomfort and usual activity, respectively. Conclusions Poor HRQoL was associated with age, comorbidities, proxy source of assessment, clinical severity and ICH characteristics. The strongest association was with initial clinical severity defined by high NIHSS score. Trial registration numbers NCT00226096 and NCT00716079; Post-results.

Original languageEnglish (US)
Pages (from-to)70-75
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume88
Issue number1
DOIs
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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    Delcourt, C., Zheng, D., Chen, X., Hackett, M., Arima, H., Hata, J., Heeley, E., Al-Shahi Salman, R., Woodward, M., Huang, Y., Robinson, T., Lavados, P. M., Lindley, R. I., Stapf, C., Davies, L., Chalmers, J., Anderson, C. S., & Sato, S. (2017). Associations with health-related quality of life after intracerebral haemorrhage: Pooled analysis of INTERACT studies. Journal of Neurology, Neurosurgery and Psychiatry, 88(1), 70-75. https://doi.org/10.1136/jnnp-2016-314414