TY - JOUR
T1 - Associations of urinary uromodulin with clinical characteristics and markers of tubular function in the general population
AU - Pruijm, Menno
AU - Ponte, Belen
AU - Ackermann, Daniel
AU - Paccaud, Fred
AU - Guessous, Idris
AU - Ehret, Georg
AU - Pechére-Bertschi, Antoinette
AU - Vogt, Bruno
AU - Mohaupt, Markus G.
AU - Martin, Pierre Yves
AU - Youhanna, Sonia C.
AU - Nägele, Nadine
AU - Vollenweider, Peter
AU - Waeber, Gérard
AU - Burnier, Michel
AU - Devuyst, Olivier
AU - Bochud, Murielle
N1 - Publisher Copyright:
© 2016 by the American Society of Nephrology.
PY - 2016/1/7
Y1 - 2016/1/7
N2 - Background and objectives Allelic variants in UMOD, the gene coding for uromodulin, are associated with rare tubulointerstitial kidney disorders and risk of CKD and hypertension in the general population. The factors associated with uromodulin excretion in the normal population remain largely unknown, and were therefore explored in this study. Design, setting, participants, & measurements Urinary uromodulin excretion was measured using a validated ELISA in two population-based cohorts that included more than 6500 individuals. The Swiss Kidney Project on Genes in Hypertension study (SKIPOGH) included 817 adults (mean age¼SD, 45¼17 years) who underwent renal ultrasonography and performed a 24-hour urine collection. The Cohorte Lausannoise study included 5706 adults (mean age, 53¼11 years) with fresh spot morning urine samples. We calculated eGFRs using the CKD- Epidemiology Collaboration formula and by 24-hour creatinine clearance. Results In both studies, positive associations were found between uromodulin and urinary sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin excretion (median, 41 [interquartile range, 29-57] mg/24 h) was positively associated with kidney length and volume and with creatinine excretion and urine volume. It was negatively associated with age and diabetes. Both spot uromodulin concentration and 24-hour uromodulin excretion were linearly and positively associated (multivariate analyses) with eGFR<90 ml/min per 1.73 m2. Conclusion Age, creatinine excretion, diabetes, and urinary volume are independent clinical correlates of urinary uromodulin excretion. The associations of uromodulin excretion with markers of tubular functions and kidney dimensions suggest that it may reflect tubule activity in the general population.
AB - Background and objectives Allelic variants in UMOD, the gene coding for uromodulin, are associated with rare tubulointerstitial kidney disorders and risk of CKD and hypertension in the general population. The factors associated with uromodulin excretion in the normal population remain largely unknown, and were therefore explored in this study. Design, setting, participants, & measurements Urinary uromodulin excretion was measured using a validated ELISA in two population-based cohorts that included more than 6500 individuals. The Swiss Kidney Project on Genes in Hypertension study (SKIPOGH) included 817 adults (mean age¼SD, 45¼17 years) who underwent renal ultrasonography and performed a 24-hour urine collection. The Cohorte Lausannoise study included 5706 adults (mean age, 53¼11 years) with fresh spot morning urine samples. We calculated eGFRs using the CKD- Epidemiology Collaboration formula and by 24-hour creatinine clearance. Results In both studies, positive associations were found between uromodulin and urinary sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin excretion (median, 41 [interquartile range, 29-57] mg/24 h) was positively associated with kidney length and volume and with creatinine excretion and urine volume. It was negatively associated with age and diabetes. Both spot uromodulin concentration and 24-hour uromodulin excretion were linearly and positively associated (multivariate analyses) with eGFR<90 ml/min per 1.73 m2. Conclusion Age, creatinine excretion, diabetes, and urinary volume are independent clinical correlates of urinary uromodulin excretion. The associations of uromodulin excretion with markers of tubular functions and kidney dimensions suggest that it may reflect tubule activity in the general population.
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U2 - 10.2215/CJN.04230415
DO - 10.2215/CJN.04230415
M3 - Article
C2 - 26683888
AN - SCOPUS:84954435534
SN - 1555-9041
VL - 11
SP - 70
EP - 80
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 1
ER -