Associations of Systemic Diseases with Intermediate Uveitis

Samir S. Shoughy, Igor Kozak, Khalid F. Tabbara

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose: To determine the associations of systemic diseases with intermediate uveitis.Methods: The medical records of 50 consecutive cases with intermediate uveitis referred to The Eye Center in Riyadh, Saudi Arabia, were reviewed. Age- and sex-matched patients without uveitis served as controls. Patients had complete ophthalmic and medical examinations.Results: There were 27 male and 23 female patients. Mean age was 29 years with a range of 5-62 years. Overall, 21 cases (42%) had systemic disorders associated with intermediate uveitis and 29 cases (58%) had no associated systemic disease. A total of 11 patients (22%) had asthma, 4 (8%) had multiple sclerosis, 3 (6%) had presumed ocular tuberculosis, 1 (2%) had inflammatory bowel disease, 1 (2%) had non-Hodgkin lymphoma and 1 (2%) had sarcoidosis. Evidence of systemic disease was found in 50 (5%) of the 1,000 control subjects. Bronchial asthma was found in 37 patients (3.7 %), multiple sclerosis in 9 patients (0.9%), inflammatory bowel disease in 3 patients (0.3%), and tuberculosis in 1 patient (0.1%). None of the control patients had sarcoidosis or lymphoma. There were statistically significant associations between intermediate uveitis and bronchial asthma (p = 0.0001), multiple sclerosis (p = 0.003) and tuberculosis (p = 0.0005).Conclusion: Bronchial asthma and multiple sclerosis were the most frequently encountered systemic diseases associated with intermediate uveitis in our patient population. Patients with intermediate uveitis should undergo careful history-taking and investigations to rule out associated systemic illness.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalOphthalmic Epidemiology
Issue number1
StatePublished - Jan 2 2016


  • Asthma
  • intermediate uveitis
  • multiple sclerosis
  • tuberculosis
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Epidemiology


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