Associations of smoking and alcohol consumption with impaired β-cell function in Chinese men

Min Xu, Yulin Zhou, Baihui Xu, Jichao Sun, Tiange Wang, Jieli Lu, Shenghan Lai, Yufang Bi, Weiqing Wang, Guang Ning

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aims of the present study were to examine the association of cigarette smoking and alcohol consumption with impaired β-cell function in Chinese men, particularly the interaction of smoking and alcohol consumption on impaired insulin secretion. Methods: A population-based cross-sectional study was performed in 3957 Chinese men aged ≥40 years. The homeostatic model assessment of β-cell function (HOMA-β) was calculated, and impaired β-cell function was defined as less than the lowest quartile HOMA-βcut-off point. Results: The prevalence of impaired β-cell function in current smokers and heavy drinkers (≥200g/week) was significantly higher than in non-smokers and non-drinkers, respectively. Compared with non-smoking, current smoking had an exacerbating relationship with impaired β-cell function (odds ratio [OR] 1.78; 95% confidence interval [CI] 1.47-2.15; P

Original languageEnglish (US)
Pages (from-to)434-441
Number of pages8
JournalJournal of Diabetes
Volume8
Issue number3
DOIs
StatePublished - May 1 2016

Keywords

  • Alcohol consumption
  • Impaired β-cell function
  • Smoking

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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