Associations of properdin factor B with melanoma

Bruce Budowle, Bruce O. Barger, Charles M. Balch, Rodney C.P. Go, Jeffrey M. Roseman, Ronald T. Acton

Research output: Contribution to journalArticle


We investigated 98 melanoma patients and 135 normal controls for differences in phenotype and genotype frequencies at the properdin factor B locus. A significant negative association with the Bf-F allele and melanoma was found, resulting in an estimated relative risk of 0.5. The estimated relative risk for developing melanoma among people with the Bf-FF genotype is 0.07. The Bf-S phenotype was significantly increased among the melanoma sample, with an estimated risk of 6.5. The data suggest association of the Bf locus with a melanoma protection and/or susceptibility gene(s).

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
JournalCancer Genetics and Cytogenetics
Issue number3
StatePublished - Mar 1982
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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  • Cite this

    Budowle, B., Barger, B. O., Balch, C. M., Go, R. C. P., Roseman, J. M., & Acton, R. T. (1982). Associations of properdin factor B with melanoma. Cancer Genetics and Cytogenetics, 5(3), 247-251.