Associations of properdin factor B with melanoma

Bruce Budowle, Bruce O. Barger, Charles M. Balch, Rodney C P Go, Jeffrey M. Roseman, Ronald T. Acton

Research output: Contribution to journalArticle

Abstract

We investigated 98 melanoma patients and 135 normal controls for differences in phenotype and genotype frequencies at the properdin factor B locus. A significant negative association with the Bf-F allele and melanoma was found, resulting in an estimated relative risk of 0.5. The estimated relative risk for developing melanoma among people with the Bf-FF genotype is 0.07. The Bf-S phenotype was significantly increased among the melanoma sample, with an estimated risk of 6.5. The data suggest association of the Bf locus with a melanoma protection and/or susceptibility gene(s).

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume5
Issue number3
DOIs
StatePublished - 1982
Externally publishedYes

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Complement Factor B
Melanoma
Genotype
Phenotype
Alleles
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Budowle, B., Barger, B. O., Balch, C. M., Go, R. C. P., Roseman, J. M., & Acton, R. T. (1982). Associations of properdin factor B with melanoma. Cancer Genetics and Cytogenetics, 5(3), 247-251. https://doi.org/10.1016/0165-4608(82)90031-0

Associations of properdin factor B with melanoma. / Budowle, Bruce; Barger, Bruce O.; Balch, Charles M.; Go, Rodney C P; Roseman, Jeffrey M.; Acton, Ronald T.

In: Cancer Genetics and Cytogenetics, Vol. 5, No. 3, 1982, p. 247-251.

Research output: Contribution to journalArticle

Budowle, B, Barger, BO, Balch, CM, Go, RCP, Roseman, JM & Acton, RT 1982, 'Associations of properdin factor B with melanoma', Cancer Genetics and Cytogenetics, vol. 5, no. 3, pp. 247-251. https://doi.org/10.1016/0165-4608(82)90031-0
Budowle, Bruce ; Barger, Bruce O. ; Balch, Charles M. ; Go, Rodney C P ; Roseman, Jeffrey M. ; Acton, Ronald T. / Associations of properdin factor B with melanoma. In: Cancer Genetics and Cytogenetics. 1982 ; Vol. 5, No. 3. pp. 247-251.
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