Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7 years

Jessie P Buckley, Lesliam Quirós-Alcalá, Susan L. Teitelbaum, Antonia M. Calafat, Mary S. Wolff, Stephanie M. Engel

Research output: Contribution to journalArticle

Abstract

Background: Prenatal environmental phenol and phthalate exposures may alter immune or inflammatory responses leading to respiratory and allergic disease. Objectives: We estimated associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic outcomes among children in the Mount Sinai Children's Environmental Health Study. Methods: We quantified urinary biomarkers of benzophenone-3, bisphenol A, paradichlorobenzene (as 2,5-dichlorophenol), triclosan, and 10 phthalate metabolites in third trimester maternal samples and assessed asthma, wheeze, and atopic skin conditions via parent questionnaires at ages 6 and 7 years (n = 164 children with 240 observations). We used logistic regression to estimate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) per standard deviation difference in natural log biomarker concentrations and examined effect measure modification by child's sex. Results: Associations of prenatal 2,5-dichlorophenol (all outcomes) and bisphenol A (asthma outcomes) were modified by child's sex, with increased odds of outcomes among boys but not girls. Among boys, ORs for asthma diagnosis per standard deviation difference in biomarker concentration were 3.00 (95% CI: 1.36, 6.59) for 2,5-dichlorophenol and 3.04 (95% CI: 1.38, 6.68) for bisphenol A. Wheeze in the past 12 months was inversely associated with low molecular weight phthalate metabolites among girls only (OR: 0.27, 95% CI: 0.13, 0.59) and with benzophenone-3 among all children (OR: 0.65, 95% CI: 0.44, 0.96). Conclusions: Prenatal bisphenol A and paradichlorobenzene exposures were associated with pediatric respiratory outcomes among boys. Future studies may shed light on biological mechanisms and potential sexually-dimorphic effects of select phenols and phthalates on respiratory disease development.

Original languageEnglish (US)
Pages (from-to)79-88
Number of pages10
JournalEnvironment International
Volume115
DOIs
StatePublished - Jun 1 2018

Fingerprint

phthalate
biomarker
phenol
confidence interval
asthma
metabolite
respiratory disease
logistics
skin

Keywords

  • Asthma
  • Bisphenol A
  • Children's health
  • Endocrine disruption
  • Environmental phenols
  • Phthalates

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7 years. / Buckley, Jessie P; Quirós-Alcalá, Lesliam; Teitelbaum, Susan L.; Calafat, Antonia M.; Wolff, Mary S.; Engel, Stephanie M.

In: Environment International, Vol. 115, 01.06.2018, p. 79-88.

Research output: Contribution to journalArticle

Buckley, Jessie P ; Quirós-Alcalá, Lesliam ; Teitelbaum, Susan L. ; Calafat, Antonia M. ; Wolff, Mary S. ; Engel, Stephanie M. / Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7 years. In: Environment International. 2018 ; Vol. 115. pp. 79-88.
@article{b6813d12e60a4eb284ebd86978d5b424,
title = "Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7 years",
abstract = "Background: Prenatal environmental phenol and phthalate exposures may alter immune or inflammatory responses leading to respiratory and allergic disease. Objectives: We estimated associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic outcomes among children in the Mount Sinai Children's Environmental Health Study. Methods: We quantified urinary biomarkers of benzophenone-3, bisphenol A, paradichlorobenzene (as 2,5-dichlorophenol), triclosan, and 10 phthalate metabolites in third trimester maternal samples and assessed asthma, wheeze, and atopic skin conditions via parent questionnaires at ages 6 and 7 years (n = 164 children with 240 observations). We used logistic regression to estimate covariate-adjusted odds ratios (ORs) and 95{\%} confidence intervals (CIs) per standard deviation difference in natural log biomarker concentrations and examined effect measure modification by child's sex. Results: Associations of prenatal 2,5-dichlorophenol (all outcomes) and bisphenol A (asthma outcomes) were modified by child's sex, with increased odds of outcomes among boys but not girls. Among boys, ORs for asthma diagnosis per standard deviation difference in biomarker concentration were 3.00 (95{\%} CI: 1.36, 6.59) for 2,5-dichlorophenol and 3.04 (95{\%} CI: 1.38, 6.68) for bisphenol A. Wheeze in the past 12 months was inversely associated with low molecular weight phthalate metabolites among girls only (OR: 0.27, 95{\%} CI: 0.13, 0.59) and with benzophenone-3 among all children (OR: 0.65, 95{\%} CI: 0.44, 0.96). Conclusions: Prenatal bisphenol A and paradichlorobenzene exposures were associated with pediatric respiratory outcomes among boys. Future studies may shed light on biological mechanisms and potential sexually-dimorphic effects of select phenols and phthalates on respiratory disease development.",
keywords = "Asthma, Bisphenol A, Children's health, Endocrine disruption, Environmental phenols, Phthalates",
author = "Buckley, {Jessie P} and Lesliam Quir{\'o}s-Alcal{\'a} and Teitelbaum, {Susan L.} and Calafat, {Antonia M.} and Wolff, {Mary S.} and Engel, {Stephanie M.}",
year = "2018",
month = "6",
day = "1",
doi = "10.1016/j.envint.2018.03.016",
language = "English (US)",
volume = "115",
pages = "79--88",
journal = "Environmental International",
issn = "0160-4120",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7 years

AU - Buckley, Jessie P

AU - Quirós-Alcalá, Lesliam

AU - Teitelbaum, Susan L.

AU - Calafat, Antonia M.

AU - Wolff, Mary S.

AU - Engel, Stephanie M.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Background: Prenatal environmental phenol and phthalate exposures may alter immune or inflammatory responses leading to respiratory and allergic disease. Objectives: We estimated associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic outcomes among children in the Mount Sinai Children's Environmental Health Study. Methods: We quantified urinary biomarkers of benzophenone-3, bisphenol A, paradichlorobenzene (as 2,5-dichlorophenol), triclosan, and 10 phthalate metabolites in third trimester maternal samples and assessed asthma, wheeze, and atopic skin conditions via parent questionnaires at ages 6 and 7 years (n = 164 children with 240 observations). We used logistic regression to estimate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) per standard deviation difference in natural log biomarker concentrations and examined effect measure modification by child's sex. Results: Associations of prenatal 2,5-dichlorophenol (all outcomes) and bisphenol A (asthma outcomes) were modified by child's sex, with increased odds of outcomes among boys but not girls. Among boys, ORs for asthma diagnosis per standard deviation difference in biomarker concentration were 3.00 (95% CI: 1.36, 6.59) for 2,5-dichlorophenol and 3.04 (95% CI: 1.38, 6.68) for bisphenol A. Wheeze in the past 12 months was inversely associated with low molecular weight phthalate metabolites among girls only (OR: 0.27, 95% CI: 0.13, 0.59) and with benzophenone-3 among all children (OR: 0.65, 95% CI: 0.44, 0.96). Conclusions: Prenatal bisphenol A and paradichlorobenzene exposures were associated with pediatric respiratory outcomes among boys. Future studies may shed light on biological mechanisms and potential sexually-dimorphic effects of select phenols and phthalates on respiratory disease development.

AB - Background: Prenatal environmental phenol and phthalate exposures may alter immune or inflammatory responses leading to respiratory and allergic disease. Objectives: We estimated associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic outcomes among children in the Mount Sinai Children's Environmental Health Study. Methods: We quantified urinary biomarkers of benzophenone-3, bisphenol A, paradichlorobenzene (as 2,5-dichlorophenol), triclosan, and 10 phthalate metabolites in third trimester maternal samples and assessed asthma, wheeze, and atopic skin conditions via parent questionnaires at ages 6 and 7 years (n = 164 children with 240 observations). We used logistic regression to estimate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) per standard deviation difference in natural log biomarker concentrations and examined effect measure modification by child's sex. Results: Associations of prenatal 2,5-dichlorophenol (all outcomes) and bisphenol A (asthma outcomes) were modified by child's sex, with increased odds of outcomes among boys but not girls. Among boys, ORs for asthma diagnosis per standard deviation difference in biomarker concentration were 3.00 (95% CI: 1.36, 6.59) for 2,5-dichlorophenol and 3.04 (95% CI: 1.38, 6.68) for bisphenol A. Wheeze in the past 12 months was inversely associated with low molecular weight phthalate metabolites among girls only (OR: 0.27, 95% CI: 0.13, 0.59) and with benzophenone-3 among all children (OR: 0.65, 95% CI: 0.44, 0.96). Conclusions: Prenatal bisphenol A and paradichlorobenzene exposures were associated with pediatric respiratory outcomes among boys. Future studies may shed light on biological mechanisms and potential sexually-dimorphic effects of select phenols and phthalates on respiratory disease development.

KW - Asthma

KW - Bisphenol A

KW - Children's health

KW - Endocrine disruption

KW - Environmental phenols

KW - Phthalates

UR - http://www.scopus.com/inward/record.url?scp=85043787838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043787838&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2018.03.016

DO - 10.1016/j.envint.2018.03.016

M3 - Article

VL - 115

SP - 79

EP - 88

JO - Environmental International

JF - Environmental International

SN - 0160-4120

ER -