Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years

Melissa N. Poulsen, Jonathan Pollak, Lisa Bailey-Davis, Annemarie G. Hirsch, Thomas A. Glass, Brian S. Schwartz

Research output: Contribution to journalArticle

Abstract

Objective: Early-life antibiotic exposure, whether through prenatal or childhood antibiotic use, may contribute to increased child body mass. Associations of prenatal and childhood antibiotic use with body mass index z-score (BMIz) were evaluated at age 3 years. Methods: Electronic health records were utilized from 8,793 mothers and singleton children delivered at Geisinger Clinic in Pennsylvania between 2006 and 2012. Antibiotic orders were ascertained for mothers during pregnancy and for children through their age-3 BMI measurement. Linear mixed-effects regression models evaluated associations of prenatal and childhood antibiotic use with child BMIz. Results: Prenatal antibiotic orders were not associated with child BMIz. Children in the three largest categories of lifetime antibiotic orders had higher BMIz compared with children with no orders; associations persisted when controlling for prenatal antibiotics (β [95% confidence interval]) (4-5 child orders: 0.090 [0.011 to 0.170]; 6 to 8: 0.113 [0.029 to 0.197]; ≥9: 0.175 [0.088 to 0.263]; trend P value <0.001). Two or more first-year orders were also associated with BMIz (1: 0.021 [−0.038 to 0.081]; 2: 0.088 [0.017 to 0.160]; ≥3: 0.104 [0.038 to 0.170]; trend P value < 0.001). Conclusions: Associations of early-life and lifetime childhood antibiotic use with increased child BMI highlight antibiotic exposure as a modifiable factor for reducing population-level excess weight.

LanguageEnglish (US)
Pages438-444
Number of pages7
JournalObesity
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2017

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Body Mass Index
Anti-Bacterial Agents
Mothers
Electronic Health Records
Confidence Intervals
Weights and Measures
Pregnancy
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years. / Poulsen, Melissa N.; Pollak, Jonathan; Bailey-Davis, Lisa; Hirsch, Annemarie G.; Glass, Thomas A.; Schwartz, Brian S.

In: Obesity, Vol. 25, No. 2, 01.02.2017, p. 438-444.

Research output: Contribution to journalArticle

Poulsen, MN, Pollak, J, Bailey-Davis, L, Hirsch, AG, Glass, TA & Schwartz, BS 2017, 'Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years' Obesity, vol. 25, no. 2, pp. 438-444. DOI: 10.1002/oby.21719
Poulsen MN, Pollak J, Bailey-Davis L, Hirsch AG, Glass TA, Schwartz BS. Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years. Obesity. 2017 Feb 1;25(2):438-444. Available from, DOI: 10.1002/oby.21719
Poulsen, Melissa N. ; Pollak, Jonathan ; Bailey-Davis, Lisa ; Hirsch, Annemarie G. ; Glass, Thomas A. ; Schwartz, Brian S./ Associations of prenatal and childhood antibiotic use with child body mass index at age 3 years. In: Obesity. 2017 ; Vol. 25, No. 2. pp. 438-444
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