Associations of plasma phospholipid omega-6 and omega-3 polyunsaturated fatty acid levels and MRI measures of cardiovascular structure and function

The multiethnic study of atherosclerosis

Jennifer S. Anderson, Jennifer A. Nettleton, W. Gregory Hundley, Michael Y. Tsai, Lyn M. Steffen, Rozenn N. Lemaitre, David Siscovick, Joao Lima, Martin R. Prince, David Herrington

Research output: Contribution to journalArticle

Abstract

Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (β = 1.89, P = 0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (β = 0.009, P = 0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.

Original languageEnglish (US)
Article number315134
JournalJournal of Nutrition and Metabolism
Volume2011
DOIs
StatePublished - 2011

Fingerprint

Docosahexaenoic Acids
Omega-3 Fatty Acids
atherosclerosis
docosahexaenoic acid
Unsaturated Fatty Acids
omega-3 fatty acids
Phospholipids
Atherosclerosis
phospholipids
alpha-Linolenic Acid
alpha-linolenic acid
magnetic resonance imaging
Stroke Volume
Omega-6 Fatty Acids
Magnetic Resonance Imaging
Eicosapentaenoic Acid
omega-6 fatty acids
Linoleic Acid
eicosapentaenoic acid
arachidonic acid

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Food Science
  • Nutrition and Dietetics

Cite this

Associations of plasma phospholipid omega-6 and omega-3 polyunsaturated fatty acid levels and MRI measures of cardiovascular structure and function : The multiethnic study of atherosclerosis. / Anderson, Jennifer S.; Nettleton, Jennifer A.; Hundley, W. Gregory; Tsai, Michael Y.; Steffen, Lyn M.; Lemaitre, Rozenn N.; Siscovick, David; Lima, Joao; Prince, Martin R.; Herrington, David.

In: Journal of Nutrition and Metabolism, Vol. 2011, 315134, 2011.

Research output: Contribution to journalArticle

Anderson, Jennifer S. ; Nettleton, Jennifer A. ; Hundley, W. Gregory ; Tsai, Michael Y. ; Steffen, Lyn M. ; Lemaitre, Rozenn N. ; Siscovick, David ; Lima, Joao ; Prince, Martin R. ; Herrington, David. / Associations of plasma phospholipid omega-6 and omega-3 polyunsaturated fatty acid levels and MRI measures of cardiovascular structure and function : The multiethnic study of atherosclerosis. In: Journal of Nutrition and Metabolism. 2011 ; Vol. 2011.
@article{e7355aa85b714249909f09bbc583ec78,
title = "Associations of plasma phospholipid omega-6 and omega-3 polyunsaturated fatty acid levels and MRI measures of cardiovascular structure and function: The multiethnic study of atherosclerosis",
abstract = "Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (β = 1.89, P = 0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (β = 0.009, P = 0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.",
author = "Anderson, {Jennifer S.} and Nettleton, {Jennifer A.} and Hundley, {W. Gregory} and Tsai, {Michael Y.} and Steffen, {Lyn M.} and Lemaitre, {Rozenn N.} and David Siscovick and Joao Lima and Prince, {Martin R.} and David Herrington",
year = "2011",
doi = "10.1155/2011/315134",
language = "English (US)",
volume = "2011",
journal = "Journal of Nutrition and Metabolism",
issn = "2090-0724",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Associations of plasma phospholipid omega-6 and omega-3 polyunsaturated fatty acid levels and MRI measures of cardiovascular structure and function

T2 - The multiethnic study of atherosclerosis

AU - Anderson, Jennifer S.

AU - Nettleton, Jennifer A.

AU - Hundley, W. Gregory

AU - Tsai, Michael Y.

AU - Steffen, Lyn M.

AU - Lemaitre, Rozenn N.

AU - Siscovick, David

AU - Lima, Joao

AU - Prince, Martin R.

AU - Herrington, David

PY - 2011

Y1 - 2011

N2 - Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (β = 1.89, P = 0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (β = 0.009, P = 0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.

AB - Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (β = 1.89, P = 0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (β = 0.009, P = 0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.

UR - http://www.scopus.com/inward/record.url?scp=84873157303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873157303&partnerID=8YFLogxK

U2 - 10.1155/2011/315134

DO - 10.1155/2011/315134

M3 - Article

VL - 2011

JO - Journal of Nutrition and Metabolism

JF - Journal of Nutrition and Metabolism

SN - 2090-0724

M1 - 315134

ER -