TY - JOUR
T1 - Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension
T2 - A meta-analysis
AU - Mahmoodi, Bakhtawar K.
AU - Matsushita, Kunihiro
AU - Woodward, Mark
AU - Blankestijn, Peter J.
AU - Cirillo, Massimo
AU - Ohkubo, Takayoshi
AU - Rossing, Peter
AU - Sarnak, Mark J.
AU - Stengel, Bénédicte
AU - Yamagishi, Kazumasa
AU - Yamashita, Kentaro
AU - Zhang, Luxia
AU - Coresh, Josef
AU - De Jong, Paul E.
AU - Astor, Brad C.
N1 - Funding Information:
The Chronic Kidney Disease Prognosis Consortium data coordinating center is underpinned by a programme grant from the US National Kidney Foundation (funding sources include Abbott and Amgen). Various sources ( appendix pp 46–48 ) have supported enrolment and data collection including laboratory measurements, and follow-up in the collaborating cohorts of the Chronic Kidney Disease Prognosis Consortium. BKM's fellowship at Johns Hopkins School of Public Health is supported by grants of Netherlands Organization for Scientific Research and the Dutch Kidney Foundation.
PY - 2012/11
Y1 - 2012/11
N2 - Background Hypertension is the most prevalent comorbidity in individuals with chronic kidney disease. However, whether the association of the kidney disease measures, estimated glomerular fi ltration rate (eGFR) and albuminuria, with mortality or end-stage renal disease (ESRD) diff ers by hypertensive status is unknown. Methods We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and ESRD associated with eGFR and albuminuria in individuals with and without hypertension. Findings We analysed data for 45 cohorts (25 general population, seven high-risk, and 13 chronic kidney disease) with 1 127 656 participants, 364 344 of whom had hypertension. Low eGFR and high albuminuria were associated with mortality irrespective of hypertensive status in the general population and high-risk cohorts. All-cause mortality risk was 1•1-1•2 times higher in individuals with hypertension than in those without hypertension at preserved eGFR. A steeper relative risk gradient in individuals without hypertension than in those with hypertension at eGFR range 45-75 mL/min per 1•73 m 2 led to much the same mortality risk at lower eGFR. With a reference eGFR of 95 mL/min per 1•73 m2 in each group to explicitly assess interaction, adjusted HR for all-cause mortality at eGFR 45 mL/min per 1•73 m2 was 1•77 (95% CI 1•57-1•99) in individuals without hypertension versus 1•24 (1•11-1•39) in those with hypertension (p for overall interaction=0•0003). Similarly, for albumin-creatinine ratio of 300 mg/g (vs 5 mg/g), HR was 2•30 (1•98-2•68) in individuals without hypertension versus 2•08 (1•84-2•35) in those with hypertension (p for overall interaction=0•019). We recorded much the same results for cardiovascular mortality. The associations of eGFR and albuminuria with ESRD, however, did not diff er by hypertensive status. Results for chronic kidney disease cohorts were similar to those for general and high-risk population cohorts.
AB - Background Hypertension is the most prevalent comorbidity in individuals with chronic kidney disease. However, whether the association of the kidney disease measures, estimated glomerular fi ltration rate (eGFR) and albuminuria, with mortality or end-stage renal disease (ESRD) diff ers by hypertensive status is unknown. Methods We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and ESRD associated with eGFR and albuminuria in individuals with and without hypertension. Findings We analysed data for 45 cohorts (25 general population, seven high-risk, and 13 chronic kidney disease) with 1 127 656 participants, 364 344 of whom had hypertension. Low eGFR and high albuminuria were associated with mortality irrespective of hypertensive status in the general population and high-risk cohorts. All-cause mortality risk was 1•1-1•2 times higher in individuals with hypertension than in those without hypertension at preserved eGFR. A steeper relative risk gradient in individuals without hypertension than in those with hypertension at eGFR range 45-75 mL/min per 1•73 m 2 led to much the same mortality risk at lower eGFR. With a reference eGFR of 95 mL/min per 1•73 m2 in each group to explicitly assess interaction, adjusted HR for all-cause mortality at eGFR 45 mL/min per 1•73 m2 was 1•77 (95% CI 1•57-1•99) in individuals without hypertension versus 1•24 (1•11-1•39) in those with hypertension (p for overall interaction=0•0003). Similarly, for albumin-creatinine ratio of 300 mg/g (vs 5 mg/g), HR was 2•30 (1•98-2•68) in individuals without hypertension versus 2•08 (1•84-2•35) in those with hypertension (p for overall interaction=0•019). We recorded much the same results for cardiovascular mortality. The associations of eGFR and albuminuria with ESRD, however, did not diff er by hypertensive status. Results for chronic kidney disease cohorts were similar to those for general and high-risk population cohorts.
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U2 - 10.1016/S0140-6736(12)61272-0
DO - 10.1016/S0140-6736(12)61272-0
M3 - Article
C2 - 23013600
AN - SCOPUS:84868588459
SN - 0140-6736
VL - 380
SP - 1649
EP - 1661
JO - The Lancet
JF - The Lancet
IS - 9854
ER -