TY - JOUR
T1 - Associations of iris structural measurements in a Chinese population
T2 - The Singapore Chinese eye study
AU - Sng, Chelvin C.
AU - Allen, John C.
AU - Nongpiur, Monisha E.
AU - Foo, Li Lian
AU - Zheng, Yingfeng
AU - Cheung, Carol Y.
AU - He, Mingguang
AU - Friedman, David S.
AU - Wong, Tien Y.
AU - Aung, Tin
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - PURPOSE. We determined the ocular biometric and demographic factors associated with iris parameters in Singaporean Chinese persons from a population-based sample. METHODS. Subjects were participants in the Singapore Chinese Eye Study, a population-based cross-sectional study of eye disease. Anterior segment optical coherence tomography images were analyzed using customized software to measure iris thickness at 750 lm from the scleral spur (IT750), iris area (I-Area), and iris curvature (I-Curv). Regression analyses were performed to assess the association between iris measurements with a range of demographic and ocular variables. The contribution of each independent variable to the iris parameter of interest was determined sequentially using a stepwise selection algorithm. RESULTS. We included 1473 participants with a mean age of 57.7 ± 8.68 years, and 50.6% were men. The mean IT750, I-Area, and I-Curv were 0.46 ± 0.10 mm, 1.49 ± 0.24 mm2, and 0.25 ± 0.13 mm, respectively. Statistical regression models, including a range of demographic and ocular parameters, explained 59.3%, 41.9%, and 34.3% of the variability in I-Curv, IT750, and I-Area, respectively. Angle opening distance at 750 μm from the scleral spur (AOD750) was the single factor associated most strongly with I-Curv, and explained 46.6% of its variation. CONCLUSIONS. A significant proportion of the variation in iris area, curvature, and thickness was not explained by other ocular and demographic parameters. Iris curvature was associated strongly with angle width, and of all parameters investigated, AOD750 was most highly correlated with iris curvature.
AB - PURPOSE. We determined the ocular biometric and demographic factors associated with iris parameters in Singaporean Chinese persons from a population-based sample. METHODS. Subjects were participants in the Singapore Chinese Eye Study, a population-based cross-sectional study of eye disease. Anterior segment optical coherence tomography images were analyzed using customized software to measure iris thickness at 750 lm from the scleral spur (IT750), iris area (I-Area), and iris curvature (I-Curv). Regression analyses were performed to assess the association between iris measurements with a range of demographic and ocular variables. The contribution of each independent variable to the iris parameter of interest was determined sequentially using a stepwise selection algorithm. RESULTS. We included 1473 participants with a mean age of 57.7 ± 8.68 years, and 50.6% were men. The mean IT750, I-Area, and I-Curv were 0.46 ± 0.10 mm, 1.49 ± 0.24 mm2, and 0.25 ± 0.13 mm, respectively. Statistical regression models, including a range of demographic and ocular parameters, explained 59.3%, 41.9%, and 34.3% of the variability in I-Curv, IT750, and I-Area, respectively. Angle opening distance at 750 μm from the scleral spur (AOD750) was the single factor associated most strongly with I-Curv, and explained 46.6% of its variation. CONCLUSIONS. A significant proportion of the variation in iris area, curvature, and thickness was not explained by other ocular and demographic parameters. Iris curvature was associated strongly with angle width, and of all parameters investigated, AOD750 was most highly correlated with iris curvature.
KW - Angle closure
KW - Epidemiology
KW - Iris
KW - Optical coherence tomography
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U2 - 10.1167/iovs.12-11250
DO - 10.1167/iovs.12-11250
M3 - Article
C2 - 23538059
AN - SCOPUS:84876577478
SN - 0146-0404
VL - 54
SP - 2829
EP - 2835
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 4
ER -