Associations of iris structural measurements in a Chinese population: The Singapore Chinese eye study

Chelvin C. Sng, John C. Allen, Monisha E. Nongpiur, Li Lian Foo, Yingfeng Zheng, Carol Y. Cheung, Mingguang He, David S. Friedman, Tien Y. Wong, Tin Aung

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


PURPOSE. We determined the ocular biometric and demographic factors associated with iris parameters in Singaporean Chinese persons from a population-based sample. METHODS. Subjects were participants in the Singapore Chinese Eye Study, a population-based cross-sectional study of eye disease. Anterior segment optical coherence tomography images were analyzed using customized software to measure iris thickness at 750 lm from the scleral spur (IT750), iris area (I-Area), and iris curvature (I-Curv). Regression analyses were performed to assess the association between iris measurements with a range of demographic and ocular variables. The contribution of each independent variable to the iris parameter of interest was determined sequentially using a stepwise selection algorithm. RESULTS. We included 1473 participants with a mean age of 57.7 ± 8.68 years, and 50.6% were men. The mean IT750, I-Area, and I-Curv were 0.46 ± 0.10 mm, 1.49 ± 0.24 mm2, and 0.25 ± 0.13 mm, respectively. Statistical regression models, including a range of demographic and ocular parameters, explained 59.3%, 41.9%, and 34.3% of the variability in I-Curv, IT750, and I-Area, respectively. Angle opening distance at 750 μm from the scleral spur (AOD750) was the single factor associated most strongly with I-Curv, and explained 46.6% of its variation. CONCLUSIONS. A significant proportion of the variation in iris area, curvature, and thickness was not explained by other ocular and demographic parameters. Iris curvature was associated strongly with angle width, and of all parameters investigated, AOD750 was most highly correlated with iris curvature.

Original languageEnglish (US)
Pages (from-to)2829-2835
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - 2013


  • Angle closure
  • Epidemiology
  • Iris
  • Optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Associations of iris structural measurements in a Chinese population: The Singapore Chinese eye study'. Together they form a unique fingerprint.

Cite this