Associations of heart rate with inflammatory markers are modulated by gender and obesity in older adults

Alice Laudisio, Stefania Bandinelli, Antonella Gemma, Luigi Ferrucci, Raffaele Antonelli Incalzi

Research output: Contribution to journalArticle

Abstract

Background. Faster resting heart rate (HR), which is associated with inflammation and elevated cortisol levels, is a risk factor for excess cardiovascular morbidity and mortality. Obesity is associated with increased cardiovascular morbidity and mortality, inflammation, and elevated cortisol levels. The aim of the present study was to evaluate the interaction of Body Mass Index (BMI) with inflammation and cortisol in modulating HR in older subjects. Methods. We analyzed data of 895 participants aged 65+ enrolled in the "InCHIANTI" study, in sinus rhythm, and not taking beta blockers or digoxin. Linear regression was performed to assess the adjusted association between HR, IL-6, and cortisol levels. The model was also analyzed stratifying for BMI tertiles. Logistic regression was adopted for evaluating the association of HR exceeding the mean value with Il-6 and serum cortisol. Results. According to multivariable linear regression, IL-6 and cortisol levels were associated with HR (B = 1.42, 95% CI = 0.43-2.42; p =. 005 and B =. 34, 95% CI = 0.17-.51; p

Original languageEnglish (US)
Pages (from-to)899-904
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume70
Issue number7
DOIs
StatePublished - Jan 11 2014
Externally publishedYes

Keywords

  • Body mass index
  • Elderly
  • Epidemiology
  • Heart rate
  • Inflammation

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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