Associations of depression status and hopelessness with breast cancer: A 24-year follow-up study

Amanda M. Mitchell, Patrick Pössel, Benjamin W. Van Voorhees, William W Eaton

Research output: Contribution to journalArticle


This study extended the literature by examining whether three profiles of depression predicted breast cancer status. In 1076 women of the Baltimore Epidemiologic Catchment Area study, depression status and hopelessness were measured at baseline and breast cancer status was ascertained 24 years later. Double depression, but not major depression or dysthymia, was associated with breast cancer. Hopelessness predicted fewer new cases of breast cancer. When double depression and hopelessness were simultaneously entered as predictors, the regression weights of both predictors increased. The role of severe and extended duration depression as well as possible explanations for unexpected findings are discussed.

Original languageEnglish (US)
Pages (from-to)1322-1331
Number of pages10
JournalJournal of Health Psychology
Issue number10
Publication statusPublished - Sep 1 2017



  • breast cancer
  • double depression
  • dysthymia
  • hopelessness
  • longitudinal design
  • major depression

ASJC Scopus subject areas

  • Applied Psychology

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