TY - JOUR
T1 - Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity
AU - Kaposi Sarcoma Working Group
AU - Brown, Elizabeth E.
AU - Fallin, Daniele
AU - Ruczinski, Ingo
AU - Hutchinson, Amy
AU - Staats, Brian
AU - Vitale, Francesco
AU - Lauria, Carmela
AU - Serraino, Diego
AU - Rezza, Giovanni
AU - Mbisa, Georgina
AU - Whitby, Denise
AU - Messina, Angelo
AU - Goedert, James J.
AU - Chanock, Stephen J.
AU - Romano, Nino
AU - Ajello, Francesca
AU - Bonura, Filippa
AU - Perna, Anna Maria
AU - Viviano, Enza
AU - Tramuto, Fabio
AU - Villafrate, Maria Rosaria
AU - Di Benedetto, Maria Antonella
AU - Tamburini, Mario
AU - Montella, Mauizio
AU - Crispo, Anna
AU - de Sicato, Sonia
AU - de Marco, Maria Rosaria
AU - Ascierto, Paolo
AU - Piselli, Pierluca
AU - Valdarchi, Catia
AU - Farchi, Francesca
AU - Corona, Rosa Maria
AU - Di Carlo, Aldo
AU - Castilletti, Concetta
AU - Gafa, Lorenzo
AU - Stella, Stefania
AU - Massimino, Michele
AU - Kroner, Barbara
AU - Chatterjee, Nilanjan
AU - Chen, Jinbo
AU - Kiley, Maureen
AU - Chen, Renee
N1 - Publisher Copyright:
© 2006 American Association for Cancer Research.
PY - 2006
Y1 - 2006
N2 - Classic Kaposi sarcoma (CKS) is an inflammatory-mediated neoplasm primarily caused by Kaposi sarcoma–associated herpesvirus (KSHV). Kaposi sarcoma lesions are characterized, in part, by the presence of proinflammatory cytokines and growth factors thought to regulate KSHV replication and CKS pathogenesis. Using genomic DNA extracted from 133 CKS cases and 172 KSHV-latent nuclear antigenpositive, population-based controls in Italy without HIV infection, we examined the risk of CKS associated with 28 common genetic variants in 14 immune-modulating genes. Haplotypes were estimated for IL1A, IL1B, IL4, IL8, IL8RB, IL10, IL12A, IL13, and TNF. Compared with controls, CKS risk was decreased with 1235T/_1010G–containing diplotypes of IL8RB (odds ratio, 0.49; 95% confidence interval, 0.30-0.78; P = 0.003), whereas risk was increased with diplotypes of IL13 containing the promoter region variant 98A (rs20541, alias +130; odds ratio, 1.88; 95% confidence interval, 1.15-3.08; P = 0.01) when considered in multivariate analysis. Risk estimates did not substantially vary by age, sex, incident disease, or disease burden. Our data provide preliminary evidence for variants in immune-modulating genes that could influence the risk of CKS. Among KSHVseropositive Italians, CKS risk was associated with diplotypes of IL8RB and IL13, supporting laboratory evidence of immune-mediated pathogenesis.
AB - Classic Kaposi sarcoma (CKS) is an inflammatory-mediated neoplasm primarily caused by Kaposi sarcoma–associated herpesvirus (KSHV). Kaposi sarcoma lesions are characterized, in part, by the presence of proinflammatory cytokines and growth factors thought to regulate KSHV replication and CKS pathogenesis. Using genomic DNA extracted from 133 CKS cases and 172 KSHV-latent nuclear antigenpositive, population-based controls in Italy without HIV infection, we examined the risk of CKS associated with 28 common genetic variants in 14 immune-modulating genes. Haplotypes were estimated for IL1A, IL1B, IL4, IL8, IL8RB, IL10, IL12A, IL13, and TNF. Compared with controls, CKS risk was decreased with 1235T/_1010G–containing diplotypes of IL8RB (odds ratio, 0.49; 95% confidence interval, 0.30-0.78; P = 0.003), whereas risk was increased with diplotypes of IL13 containing the promoter region variant 98A (rs20541, alias +130; odds ratio, 1.88; 95% confidence interval, 1.15-3.08; P = 0.01) when considered in multivariate analysis. Risk estimates did not substantially vary by age, sex, incident disease, or disease burden. Our data provide preliminary evidence for variants in immune-modulating genes that could influence the risk of CKS. Among KSHVseropositive Italians, CKS risk was associated with diplotypes of IL8RB and IL13, supporting laboratory evidence of immune-mediated pathogenesis.
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U2 - 10.1158/1055-9965.EPI-05-0791
DO - 10.1158/1055-9965.EPI-05-0791
M3 - Article
C2 - 16702372
AN - SCOPUS:33744813534
SN - 1055-9965
VL - 15
SP - 926
EP - 934
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -