Associations of body composition measures and C2, a marker for small artery elasticity: The MESA

Nketi I. Forbang, Matthew A. Allison, Joachim H. Ix, Michael H. Criqui, Dhananjay Vaidya, Joseph Yeboah, Daniel A. Duprez, David R. Jacobs

Research output: Contribution to journalArticle

Abstract

Objective Lower C2, a continuous blood pressure waveform characteristic asserted to represent small artery elasticity, predicts future cardiovascular disease events. It is hypothesized that the paradoxical positive association between body mass index (BMI) and C2 may reflect muscle instead of excess fat. Methods In a multi-ethnic, community-living cohort of 1,960 participants, computed tomography scans of the abdomen were used to measure visceral adipose tissue (VAT) and total abdominal muscle tissue (TAMT), and applanation tonometry of the radial arteries was used to assess C2. The period cross-sectional associations between BMI, TAMT, and VAT with C2 were ascertained. Results The mean age was 62 ± 9 years and 51% were male. After adjustments for age, gender, ethnicity, pack years smoking cigarettes, diabetes, hypertension, and total and HDL cholesterol, higher BMI (standardized beta = 0.09, P-value <0.01) and more TAMT (standardized beta = 0.12, P-value <0.01) were significantly associated with higher C2. In contrast, more VAT (standardized beta = -0.09, P-value <0.01) was associated with lower C2. Conclusions In multivariable analysis, VAT, in contrast to TAMT and BMI, was associated with less compliant small arteries. Visceral fat may be a better marker for detrimental excess body fat than BMI.

Original languageEnglish (US)
Pages (from-to)2294-2298
Number of pages5
JournalObesity
Volume23
Issue number11
DOIs
StatePublished - Nov 1 2015

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Body Weights and Measures
Intra-Abdominal Fat
Elasticity
Abdominal Muscles
Body Composition
Body Mass Index
Arteries
Muscles
Radial Artery
Fat Body
Manometry
Abdomen
HDL Cholesterol
Adipose Tissue
Cardiovascular Diseases
Smoking
Fats
Tomography
Blood Pressure
Hypertension

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Forbang, N. I., Allison, M. A., Ix, J. H., Criqui, M. H., Vaidya, D., Yeboah, J., ... Jacobs, D. R. (2015). Associations of body composition measures and C2, a marker for small artery elasticity: The MESA. Obesity, 23(11), 2294-2298. https://doi.org/10.1002/oby.21221

Associations of body composition measures and C2, a marker for small artery elasticity : The MESA. / Forbang, Nketi I.; Allison, Matthew A.; Ix, Joachim H.; Criqui, Michael H.; Vaidya, Dhananjay; Yeboah, Joseph; Duprez, Daniel A.; Jacobs, David R.

In: Obesity, Vol. 23, No. 11, 01.11.2015, p. 2294-2298.

Research output: Contribution to journalArticle

Forbang, NI, Allison, MA, Ix, JH, Criqui, MH, Vaidya, D, Yeboah, J, Duprez, DA & Jacobs, DR 2015, 'Associations of body composition measures and C2, a marker for small artery elasticity: The MESA', Obesity, vol. 23, no. 11, pp. 2294-2298. https://doi.org/10.1002/oby.21221
Forbang, Nketi I. ; Allison, Matthew A. ; Ix, Joachim H. ; Criqui, Michael H. ; Vaidya, Dhananjay ; Yeboah, Joseph ; Duprez, Daniel A. ; Jacobs, David R. / Associations of body composition measures and C2, a marker for small artery elasticity : The MESA. In: Obesity. 2015 ; Vol. 23, No. 11. pp. 2294-2298.
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