Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability

The multi-ethnic study of atherosclerosis (MESA)

Daichi Shimbo, Steven Shea, Robyn L. McClelland, Anthony J. Viera, Devin Mann, Jonathan Newman, Joao Lima, Joseph F. Polak, Bruce M. Psaty, Paul Muntner

Research output: Contribution to journalArticle

Abstract

Background Although higher visit-to-visit variability (VVV) of blood pressure (BP) is associated with increased cardiovascular disease risk, the physiological basis for VVV of BP is incompletely understood. Methods We examined the associations of aortic distensibility (assessed by magnetic resonance imaging) and artery elasticity indices (determined by radial artery pulse contour analysis) with VVV of BP in 2,640 and 4,560 participants, respectively, from the Multi-Ethnic Study of Atherosclerosis. Arterial measures were obtained at exam 1. BP readings were taken at exam 1 and at 3 follow-up visits at 18-month intervals (exams 2, 3, and 4). VVV was defined as the SD about each participant's mean systolic BP (SBP) across visits. Results The mean SDs of SBP were inversely associated with aortic distensibility: 7.7, 9.9, 10.9, and 13.2mm Hg for quartiles 4, 3, 2, and 1 of aortic distensibility, respectively (P trend <0.001). This association remained significant after adjustment for demographics, cardiovascular risk factors, mean SBP, and antihypertensive medication use (P trend <0.01). In a fully adjusted model, lower quartiles of large artery and small artery elasticity (LAE and SAE) indices were also associated with higher mean SD of SBP (P trend = 0.02 for LAE; P trend <0.001 for SAE). Conclusions In this multiethnic cohort, functional alterations of central and peripheral arteries were associated with greater long-term VVV of SBP.

Original languageEnglish (US)
Pages (from-to)896-902
Number of pages7
JournalAmerican Journal of Hypertension
Volume26
Issue number7
DOIs
StatePublished - Jul 2013

Fingerprint

Elasticity
Atherosclerosis
Blood Pressure
Arteries
Radial Artery
Antihypertensive Agents
Pulse
Reading
Cardiovascular Diseases
Magnetic Resonance Imaging
Demography

Keywords

  • arteries
  • blood pressure
  • epidemiology
  • hypertension
  • vasculature

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability : The multi-ethnic study of atherosclerosis (MESA). / Shimbo, Daichi; Shea, Steven; McClelland, Robyn L.; Viera, Anthony J.; Mann, Devin; Newman, Jonathan; Lima, Joao; Polak, Joseph F.; Psaty, Bruce M.; Muntner, Paul.

In: American Journal of Hypertension, Vol. 26, No. 7, 07.2013, p. 896-902.

Research output: Contribution to journalArticle

Shimbo, Daichi ; Shea, Steven ; McClelland, Robyn L. ; Viera, Anthony J. ; Mann, Devin ; Newman, Jonathan ; Lima, Joao ; Polak, Joseph F. ; Psaty, Bruce M. ; Muntner, Paul. / Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability : The multi-ethnic study of atherosclerosis (MESA). In: American Journal of Hypertension. 2013 ; Vol. 26, No. 7. pp. 896-902.
@article{5af5443872de40f7be4092e798cde964,
title = "Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability: The multi-ethnic study of atherosclerosis (MESA)",
abstract = "Background Although higher visit-to-visit variability (VVV) of blood pressure (BP) is associated with increased cardiovascular disease risk, the physiological basis for VVV of BP is incompletely understood. Methods We examined the associations of aortic distensibility (assessed by magnetic resonance imaging) and artery elasticity indices (determined by radial artery pulse contour analysis) with VVV of BP in 2,640 and 4,560 participants, respectively, from the Multi-Ethnic Study of Atherosclerosis. Arterial measures were obtained at exam 1. BP readings were taken at exam 1 and at 3 follow-up visits at 18-month intervals (exams 2, 3, and 4). VVV was defined as the SD about each participant's mean systolic BP (SBP) across visits. Results The mean SDs of SBP were inversely associated with aortic distensibility: 7.7, 9.9, 10.9, and 13.2mm Hg for quartiles 4, 3, 2, and 1 of aortic distensibility, respectively (P trend <0.001). This association remained significant after adjustment for demographics, cardiovascular risk factors, mean SBP, and antihypertensive medication use (P trend <0.01). In a fully adjusted model, lower quartiles of large artery and small artery elasticity (LAE and SAE) indices were also associated with higher mean SD of SBP (P trend = 0.02 for LAE; P trend <0.001 for SAE). Conclusions In this multiethnic cohort, functional alterations of central and peripheral arteries were associated with greater long-term VVV of SBP.",
keywords = "arteries, blood pressure, epidemiology, hypertension, vasculature",
author = "Daichi Shimbo and Steven Shea and McClelland, {Robyn L.} and Viera, {Anthony J.} and Devin Mann and Jonathan Newman and Joao Lima and Polak, {Joseph F.} and Psaty, {Bruce M.} and Paul Muntner",
year = "2013",
month = "7",
doi = "10.1093/ajh/hpt040",
language = "English (US)",
volume = "26",
pages = "896--902",
journal = "Journal of clinical hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability

T2 - The multi-ethnic study of atherosclerosis (MESA)

AU - Shimbo, Daichi

AU - Shea, Steven

AU - McClelland, Robyn L.

AU - Viera, Anthony J.

AU - Mann, Devin

AU - Newman, Jonathan

AU - Lima, Joao

AU - Polak, Joseph F.

AU - Psaty, Bruce M.

AU - Muntner, Paul

PY - 2013/7

Y1 - 2013/7

N2 - Background Although higher visit-to-visit variability (VVV) of blood pressure (BP) is associated with increased cardiovascular disease risk, the physiological basis for VVV of BP is incompletely understood. Methods We examined the associations of aortic distensibility (assessed by magnetic resonance imaging) and artery elasticity indices (determined by radial artery pulse contour analysis) with VVV of BP in 2,640 and 4,560 participants, respectively, from the Multi-Ethnic Study of Atherosclerosis. Arterial measures were obtained at exam 1. BP readings were taken at exam 1 and at 3 follow-up visits at 18-month intervals (exams 2, 3, and 4). VVV was defined as the SD about each participant's mean systolic BP (SBP) across visits. Results The mean SDs of SBP were inversely associated with aortic distensibility: 7.7, 9.9, 10.9, and 13.2mm Hg for quartiles 4, 3, 2, and 1 of aortic distensibility, respectively (P trend <0.001). This association remained significant after adjustment for demographics, cardiovascular risk factors, mean SBP, and antihypertensive medication use (P trend <0.01). In a fully adjusted model, lower quartiles of large artery and small artery elasticity (LAE and SAE) indices were also associated with higher mean SD of SBP (P trend = 0.02 for LAE; P trend <0.001 for SAE). Conclusions In this multiethnic cohort, functional alterations of central and peripheral arteries were associated with greater long-term VVV of SBP.

AB - Background Although higher visit-to-visit variability (VVV) of blood pressure (BP) is associated with increased cardiovascular disease risk, the physiological basis for VVV of BP is incompletely understood. Methods We examined the associations of aortic distensibility (assessed by magnetic resonance imaging) and artery elasticity indices (determined by radial artery pulse contour analysis) with VVV of BP in 2,640 and 4,560 participants, respectively, from the Multi-Ethnic Study of Atherosclerosis. Arterial measures were obtained at exam 1. BP readings were taken at exam 1 and at 3 follow-up visits at 18-month intervals (exams 2, 3, and 4). VVV was defined as the SD about each participant's mean systolic BP (SBP) across visits. Results The mean SDs of SBP were inversely associated with aortic distensibility: 7.7, 9.9, 10.9, and 13.2mm Hg for quartiles 4, 3, 2, and 1 of aortic distensibility, respectively (P trend <0.001). This association remained significant after adjustment for demographics, cardiovascular risk factors, mean SBP, and antihypertensive medication use (P trend <0.01). In a fully adjusted model, lower quartiles of large artery and small artery elasticity (LAE and SAE) indices were also associated with higher mean SD of SBP (P trend = 0.02 for LAE; P trend <0.001 for SAE). Conclusions In this multiethnic cohort, functional alterations of central and peripheral arteries were associated with greater long-term VVV of SBP.

KW - arteries

KW - blood pressure

KW - epidemiology

KW - hypertension

KW - vasculature

UR - http://www.scopus.com/inward/record.url?scp=84878843172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878843172&partnerID=8YFLogxK

U2 - 10.1093/ajh/hpt040

DO - 10.1093/ajh/hpt040

M3 - Article

VL - 26

SP - 896

EP - 902

JO - Journal of clinical hypertension

JF - Journal of clinical hypertension

SN - 0895-7061

IS - 7

ER -