Associations of allelic differences at the A-I/C-III/A-IV gene cluster with carotid artery intima-media thickness and plasma lipid transport in hypercholesterolemic-hypertriglyceridemic humans

Wolfgang Patsch, A. Richey Sharrett, Iou Y. Chen, Yen Chiu Lin-Lee, Spencer A. Brown, Antonio M. Gotto, Eric Boerwinkle

Research output: Contribution to journalArticle

Abstract

Individuals with elevated levels of plasma cholesterol and triglyceride may be at higher risk for coronary artery disease than those with isolated elevations of either cholesterol or triglyceride. Sequence variation in the A-I/C-III/A-IV gene cluster has been implicated in the etiology of some disorders associated with premature atherosclerosis and/or hypertriglyceridemias with or without elevations of cholesterol. This led to. the hypothesis that allelic variation at this gene locus alters plasma lipid transport and affects susceptibility for atherosclerosis. The study population, from the Atherosclerosis Risk in Communities (ARIC) Study, consisted of 50 normolipidemic individuals, 48 subjects with elevated plasma cholesterol, 47 subjects with elevated plasma triglyceride, and 123 subjects with both elevated plasma cholesterol and triglyceride who were used to evaluate associations between an Xmn I polymorphic site 2.5 kilobase pairs (kbp) upstream of the structural gene for apolipoprotein (apo) A-I, intimal-medial thickening of the extracranial carotid arteries, and several plasma lipid factors. The relative allele frequencies of the 8.3-kbp allele and the 6.6-kbp allele were .86 and .14, respectively, in the entire study population and did not differ among the lipid phenotypes. In the group with elevated plasma cholesterol and triglyceride, subjects possessing the 6.6-kbp allele exhibited a greater carotid artery intimal-medial thickness (P=.034) and higher plasma levels of apoA-I, high-density lipoprotein (HDL) cholesterol, and HDL3 cholesterol (P

Original languageEnglish (US)
Pages (from-to)874-883
Number of pages10
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume14
Issue number6
StatePublished - 1994
Externally publishedYes

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Carotid Intima-Media Thickness
Multigene Family
Carotid Arteries
Lipids
Triglycerides
Hypercholesterolemia
Tunica Intima
Atherosclerosis
Alleles
Apolipoprotein A-I
Cholesterol
HDL Cholesterol
HDL3 Lipoprotein
Gene Frequency
Population
Genes
Coronary Artery Disease
Phenotype

Keywords

  • Apolipoproteins
  • Carotid atherosclerosis
  • Gene expression
  • Hyperlipidemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Associations of allelic differences at the A-I/C-III/A-IV gene cluster with carotid artery intima-media thickness and plasma lipid transport in hypercholesterolemic-hypertriglyceridemic humans. / Patsch, Wolfgang; Richey Sharrett, A.; Chen, Iou Y.; Lin-Lee, Yen Chiu; Brown, Spencer A.; Gotto, Antonio M.; Boerwinkle, Eric.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 14, No. 6, 1994, p. 874-883.

Research output: Contribution to journalArticle

Patsch, Wolfgang ; Richey Sharrett, A. ; Chen, Iou Y. ; Lin-Lee, Yen Chiu ; Brown, Spencer A. ; Gotto, Antonio M. ; Boerwinkle, Eric. / Associations of allelic differences at the A-I/C-III/A-IV gene cluster with carotid artery intima-media thickness and plasma lipid transport in hypercholesterolemic-hypertriglyceridemic humans. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 1994 ; Vol. 14, No. 6. pp. 874-883.
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