TY - JOUR
T1 - Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania
AU - Tustin, Aaron W.
AU - Hirsch, Annemarie G.
AU - Rasmussen, Sara G.
AU - Casey, Joan A.
AU - Bandeen-Roche, Karen
AU - Schwartz, Brian S.
N1 - Funding Information:
This research was funded by National Institutes of Health grants U19 AI106683 (PI R. Schleimer; A.G.H., B.S.S.), R21 ES023675 (B.S.S.), and training grant ES07141 (S.G.R.); the Robert Wood Johnson Foundation (J.A.C.); the Degenstein Foundation; and the National Science Foundation Integrative Graduate Education and Research Traineeship (S.G.R.).
Publisher Copyright:
© 2017, Public Health Services, US Dept of Health and Human Services. All rights reserved.
PY - 2017/2
Y1 - 2017/2
N2 - Background: Unconventional natural gas development (UNGD) produces environmental contaminants and psychosocial stressors. Despite these concerns, few studies have evaluated the health effects of UNGD. Objectives: We investigated associations between UNGD activity and symptoms in a cross-sectional study in Pennsylvania. Methods: We mailed a self-administered questionnaire to 23,700 adult patients of the Geisinger Clinic. Using standardized and validated questionnaire items, we identified respondents with chronic rhinosinusitis (CRS), migraine headache, and fatigue symptoms. We created a summary UNGD activity metric that incorporated well phase, location, total depth, daily gas production and inverse distance–squared to patient residences. We used logistic regression, weighted for sampling and response rates, to assess associations between quartiles of UNGD activity and outcomes, both alone and in combination. Results: The response rate was 33%. Of 7,785 study participants, 1,850 (24%) had current CRS symptoms, 1,765 (23%) had migraine headache, and 1,930 (25%) had higher levels of fatigue. Among individuals who met criteria for two or more outcomes, adjusted odds ratios for the highest quartile of UNGD activity compared with the lowest were [OR (95% CI)] 1.49 (0.78, 2.85) for CRS plus migraine, 1.88 (1.08, 3.25) for CRS plus fatigue, 1.95 (1.18, 3.21) for migraine plus fatigue, and 1.84 (1.08, 3.14) for all three outcomes together. Significant associations were also present in some models of single outcomes. Conclusions: This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample.
AB - Background: Unconventional natural gas development (UNGD) produces environmental contaminants and psychosocial stressors. Despite these concerns, few studies have evaluated the health effects of UNGD. Objectives: We investigated associations between UNGD activity and symptoms in a cross-sectional study in Pennsylvania. Methods: We mailed a self-administered questionnaire to 23,700 adult patients of the Geisinger Clinic. Using standardized and validated questionnaire items, we identified respondents with chronic rhinosinusitis (CRS), migraine headache, and fatigue symptoms. We created a summary UNGD activity metric that incorporated well phase, location, total depth, daily gas production and inverse distance–squared to patient residences. We used logistic regression, weighted for sampling and response rates, to assess associations between quartiles of UNGD activity and outcomes, both alone and in combination. Results: The response rate was 33%. Of 7,785 study participants, 1,850 (24%) had current CRS symptoms, 1,765 (23%) had migraine headache, and 1,930 (25%) had higher levels of fatigue. Among individuals who met criteria for two or more outcomes, adjusted odds ratios for the highest quartile of UNGD activity compared with the lowest were [OR (95% CI)] 1.49 (0.78, 2.85) for CRS plus migraine, 1.88 (1.08, 3.25) for CRS plus fatigue, 1.95 (1.18, 3.21) for migraine plus fatigue, and 1.84 (1.08, 3.14) for all three outcomes together. Significant associations were also present in some models of single outcomes. Conclusions: This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample.
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U2 - 10.1289/EHP281
DO - 10.1289/EHP281
M3 - Article
C2 - 27561132
AN - SCOPUS:85011410556
SN - 0091-6765
VL - 125
SP - 189
EP - 197
JO - Environmental health perspectives
JF - Environmental health perspectives
IS - 2
ER -