Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development

Laura A. Schieve, Lin Tian, Nicole Dowling, Lisa Croen, Julie E Hoover Fong, Aimee Alexander, Stuart K. Shapira

Research output: Contribution to journalArticle

Abstract

The ratio of the index (2nd) finger to ring (4th) finger lengths (2D:4D) is a proxy for fetal testosterone and estradiol. Studies suggesting 2D:4D is inversely associated with autism spectrum disorder (ASD) in males were limited by lack of confounder and subgroup assessments. Studies of females are sparse. We examined associations between ASD and 2D:4D among children in the Study to Explore Early Development; we considered case subgroups and numerous potential demographic and maternal-perinatal health confounders. We observed a modest inverse association between ASD and right-hand 2D:4D in males; subgroup analyses indicated associations were limited to ASD cases with birth defects/genetic syndromes or dysmorphic features. We observed a positive association between ASD and left-hand 2D:4D in females, overall and within most case subgroups.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalJournal of Autism and Developmental Disorders
DOIs
StateAccepted/In press - Feb 15 2018

Fingerprint

Population
Fingers
Hand
Proxy
Testosterone
Estradiol
Demography
Autism Spectrum Disorder
Maternal Health

Keywords

  • Autism spectrum disorder
  • Estradiol
  • Fetal development
  • Testosterone

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls : Findings from the Study to Explore Early Development. / Schieve, Laura A.; Tian, Lin; Dowling, Nicole; Croen, Lisa; Hoover Fong, Julie E; Alexander, Aimee; Shapira, Stuart K.

In: Journal of Autism and Developmental Disorders, 15.02.2018, p. 1-17.

Research output: Contribution to journalArticle

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