Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: A systematic review and meta-analysis

L. Y. Han, Q. H. Wu, M. L. Jiao, Y. H. Hao, L. B. Liang, L. J. Gao, D. G. Legge, H. Quan, M. M. Zhao, N. Ning, Z. Kang, H. Sun

Research output: Contribution to journalArticlepeer-review

Abstract

Aims/hypothesis The associations between adiponectin polymorphisms and type 2 diabetes have been studied widely; however, results are inconsistent. Methods We searched electronic literature databases and reference lists of relevant articles. A fixed or random effects model was used on the basis of heterogeneity. Sub-group and meta-regression analyses were conducted to explore the sources of heterogeneity. Results There were no statistically significant associations between +45T>G (rs2241766), +276G>T (rs1501299), -11391G>A (rs17300539) and type 2 diabetes risk. However, for -11377C>G (rs266729), the pooled OR (95% CI) for G vs C allele was 1.07 (1.03-1.11, p=0.001). Subgroup analysis by study design revealed that -11377C>G (rs266729) dominant model (CG+GG vs CC, p=0.0008) and G vs C allele (p=0.0004) might be associated with type 2 diabetes risk in population-based case-control studies. After stratification by ethnicity, we found that -11377C>G (rs266729) dominant model (CG+GG vs CC, p=0.004) and G vs C allele (p=0.001) might be associated with type 2 diabetes risk in white individuals. In individuals with a family history of diabetes, the presence of -11391G>A (rs17300539) dominant model (GA+AA vs GG) and A vs G allele might be associated with increased risk of type 2 diabetes. Conclusions/interpretation The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes. However, G vs C allele of -11377C>G (rs266729) might be a risk factor for type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)2303-2314
Number of pages12
JournalDiabetologia
Volume54
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • Adiponectin
  • ADIPOQ
  • Gene
  • Meta-analysis
  • SNP
  • Systematic review
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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