TY - JOUR
T1 - Associations between serum folate and vitamin D levels and incident mouse sensitization in adults
AU - Keet, Corinne A.
AU - Shreffler, Wayne G.
AU - Peng, Roger D.
AU - Matsui, William
AU - Matsui, Elizabeth C.
N1 - Funding Information:
Disclosure of potential conflict of interest: R. D. Peng has received royalties from Springer Publishing . W. Matsui has consultancy arrangements with Infinity Pharmaceuticals, Johnson and Johnson, and the National Institutes of Health (NIH)/National Cancer Institute's Cancer Therapy Evaluation Program; has received one or more grants from or has one or more grants pending with Geron Corporation ; and has received one or more payments for travel/accommodations/meeting expenses from the NIH, the Leukemia Lymphoma Society, Gabrielle's Angel Cancer Foundation, the University of Arizona, MD Anderson Cancer Center, the California Institute of Regenerative Medicine, the Ontario Institute for Cancer Research, Arrowhead Publishing, Washington University, Harvard School of Public Health, AACR, Cellerant Co, ASBMT, ASH, and the Canadian Society for Pharmaceutical Sciences . E. C. Matsui has been supported by one or more grants from the NIH ; is a member of the US Environmental Protection Agency Science Advisory Board and the National Institute of Environmental Health Sciences Environmental Health Sciences Review Committee ; and has received one or more payments for the development of educational presentations for Thermo Fisher. The rest of the authors declare that they have no relevant conflicts of interest.
Funding Information:
Supported in part by National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH) grant no. 1K23AI103187 (to C.A.K.) and NIAID/NIH grant no. R01AI081845 (to E.C.M.).
PY - 2014/2
Y1 - 2014/2
N2 - Background Although both folic acid intake and vitamin D levels are hypothesized to be contributors to the increased incidence of allergic diseases, prospective studies of these relationships have not been done in adults. Objectives We sought to determine whether serum folate or vitamin D levels are associated with incident mouse sensitization among new workers at a mouse facility. Methods Subjects started employment at the Jackson Laboratory between June 2004 and July 2007. Skin testing to mouse and other allergens and collection of questionnaire data were performed at baseline and every 6 months. Serum folate and vitamin D levels were assessed on baseline samples stored at -80 C. Folate was categorized into tertiles (2.5-10.5, 10.5-16.2, and 16.2-78.4 ng/mL, respectively). Vitamin D was categorized as less than 20 ng/mL, 20 to 29 ng/mL, or 30 ng/mL or greater. This was a nested case-control study in which 5 control subjects were matched to each case on baseline atopy and type of employment. Multivariate analyses controlled for age, sex, education, smoking, season, personal mouse exposure, and serum folate and vitamin D levels. Results Thirty-five cases and 47 control subjects were included. The odds of incident mouse sensitization were higher in the intermediate and highest tertiles of serum folate compared with the lowest tertile of serum folate (odds ratio of 10.5 [95% CI, 1.8-61.5; P =.009] and odds ratio of 5.6 [95% CI, 1.8-31.3; P =.049], respectively, in the multivariate model). Serum vitamin D levels were not associated with incident mouse sensitization. Conclusions These findings support a role for higher serum folate levels in increased risk of incident allergic disease, even during adulthood.
AB - Background Although both folic acid intake and vitamin D levels are hypothesized to be contributors to the increased incidence of allergic diseases, prospective studies of these relationships have not been done in adults. Objectives We sought to determine whether serum folate or vitamin D levels are associated with incident mouse sensitization among new workers at a mouse facility. Methods Subjects started employment at the Jackson Laboratory between June 2004 and July 2007. Skin testing to mouse and other allergens and collection of questionnaire data were performed at baseline and every 6 months. Serum folate and vitamin D levels were assessed on baseline samples stored at -80 C. Folate was categorized into tertiles (2.5-10.5, 10.5-16.2, and 16.2-78.4 ng/mL, respectively). Vitamin D was categorized as less than 20 ng/mL, 20 to 29 ng/mL, or 30 ng/mL or greater. This was a nested case-control study in which 5 control subjects were matched to each case on baseline atopy and type of employment. Multivariate analyses controlled for age, sex, education, smoking, season, personal mouse exposure, and serum folate and vitamin D levels. Results Thirty-five cases and 47 control subjects were included. The odds of incident mouse sensitization were higher in the intermediate and highest tertiles of serum folate compared with the lowest tertile of serum folate (odds ratio of 10.5 [95% CI, 1.8-61.5; P =.009] and odds ratio of 5.6 [95% CI, 1.8-31.3; P =.049], respectively, in the multivariate model). Serum vitamin D levels were not associated with incident mouse sensitization. Conclusions These findings support a role for higher serum folate levels in increased risk of incident allergic disease, even during adulthood.
KW - Folate
KW - allergy
KW - folic acid
KW - mouse allergy
KW - sensitization
KW - vitamin D
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U2 - 10.1016/j.jaci.2013.09.042
DO - 10.1016/j.jaci.2013.09.042
M3 - Article
C2 - 24290285
AN - SCOPUS:84895058771
SN - 0091-6749
VL - 133
SP - 399
EP - 404
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 2
ER -