Associations between personal exposure to air pollutants and lung function tests and cardiovascular indices among children with asthma living near an industrial complex and petroleum refineries

Audrey Smargiassi, Mark S. Goldberg, Amanda J. Wheeler, Céline Plante, Marie France Valois, Gary Mallach, Lisa Marie Kauri, Robin Shutt, Susan Bartlett, Marie Raphoz, Ling Liu

Research output: Contribution to journalArticle

Abstract

Objective: The acute cardiorespiratory effects of air quality among children living in areas with considerable heavy industry have not been well investigated. We conducted a panel study of children with asthma living in proximity to an industrial complex housing two refineries in Montreal, Quebec, in order to assess associations between their personal daily exposure to air pollutants and changes in pulmonary function and selected indicators of cardiovascular health. Methods: Seventy-two children with asthma age 7-12 years in 2009-2010 participated in this panel study for a period of 10 consecutive days. They carried a small backpack for personal monitoring of sulphur dioxide (SO2), benzene, fine particles (PM2.5), nitrogen dioxide (NO2) and polycyclic aromatic hydrocarbons (PAHs) and underwent daily spirometry and cardiovascular testing (blood pressure, pulse rate and oxygen saturation). To estimate these associations, we used mixed regression models, adjusting for within-subject serial correlation, and for the effects of a number of personal and environmental variables (e.g., medication use, ethnicity, temperature). Results: Children with asthma involved in the study had relatively good pulmonary function test results (mean FEV1 compared to standard values: 89.8%, mean FVC: 97.6%, mean FEF25-75: 76.3%). Median diastolic, systolic blood pressures and oxygen saturation were 60/94mmHg and 99%, respectively. Median personal concentrations of pollutants were NO2, 5.5ppb; benzene, 2.1μg/m3; PM2.5, 5.7μg/m3; and total PAH, 130μg/m3. Most personal concentrations of SO2 were below the level of detection. No consistent associations were observed between cardio-pulmonary indices and personal exposure to PM2.5, NO2 and benzene, although there was a suggestion for a small decrease in respiratory function with total concentrations of PAHs (e.g., adjusted association with FVC: -9.9ml per interquartile range 95%CI: -23.4, 3.7). Conclusions: This study suggests that at low daily average levels of exposure to industrial emissions, effects on pulmonary and cardiovascular functions in children with asthma may be difficult to detect over 10 consecutive days.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalEnvironmental Research
Volume132
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Petroleum refineries
Air Pollutants
asthma
Respiratory Function Tests
Petroleum
Polycyclic Aromatic Hydrocarbons
Asthma
Benzene
petroleum
Blood pressure
benzene
PAH
Blood Pressure
Lung
Industrial emissions
Oxygen
Nitrogen Dioxide
Sulfur Dioxide
blood
Metallurgy

Keywords

  • Air pollution
  • Asthma
  • Industrial emissions
  • Pulmonary functions
  • Refineries

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry

Cite this

Associations between personal exposure to air pollutants and lung function tests and cardiovascular indices among children with asthma living near an industrial complex and petroleum refineries. / Smargiassi, Audrey; Goldberg, Mark S.; Wheeler, Amanda J.; Plante, Céline; Valois, Marie France; Mallach, Gary; Kauri, Lisa Marie; Shutt, Robin; Bartlett, Susan; Raphoz, Marie; Liu, Ling.

In: Environmental Research, Vol. 132, 2014, p. 38-45.

Research output: Contribution to journalArticle

Smargiassi, Audrey ; Goldberg, Mark S. ; Wheeler, Amanda J. ; Plante, Céline ; Valois, Marie France ; Mallach, Gary ; Kauri, Lisa Marie ; Shutt, Robin ; Bartlett, Susan ; Raphoz, Marie ; Liu, Ling. / Associations between personal exposure to air pollutants and lung function tests and cardiovascular indices among children with asthma living near an industrial complex and petroleum refineries. In: Environmental Research. 2014 ; Vol. 132. pp. 38-45.
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abstract = "Objective: The acute cardiorespiratory effects of air quality among children living in areas with considerable heavy industry have not been well investigated. We conducted a panel study of children with asthma living in proximity to an industrial complex housing two refineries in Montreal, Quebec, in order to assess associations between their personal daily exposure to air pollutants and changes in pulmonary function and selected indicators of cardiovascular health. Methods: Seventy-two children with asthma age 7-12 years in 2009-2010 participated in this panel study for a period of 10 consecutive days. They carried a small backpack for personal monitoring of sulphur dioxide (SO2), benzene, fine particles (PM2.5), nitrogen dioxide (NO2) and polycyclic aromatic hydrocarbons (PAHs) and underwent daily spirometry and cardiovascular testing (blood pressure, pulse rate and oxygen saturation). To estimate these associations, we used mixed regression models, adjusting for within-subject serial correlation, and for the effects of a number of personal and environmental variables (e.g., medication use, ethnicity, temperature). Results: Children with asthma involved in the study had relatively good pulmonary function test results (mean FEV1 compared to standard values: 89.8{\%}, mean FVC: 97.6{\%}, mean FEF25-75: 76.3{\%}). Median diastolic, systolic blood pressures and oxygen saturation were 60/94mmHg and 99{\%}, respectively. Median personal concentrations of pollutants were NO2, 5.5ppb; benzene, 2.1μg/m3; PM2.5, 5.7μg/m3; and total PAH, 130μg/m3. Most personal concentrations of SO2 were below the level of detection. No consistent associations were observed between cardio-pulmonary indices and personal exposure to PM2.5, NO2 and benzene, although there was a suggestion for a small decrease in respiratory function with total concentrations of PAHs (e.g., adjusted association with FVC: -9.9ml per interquartile range 95{\%}CI: -23.4, 3.7). Conclusions: This study suggests that at low daily average levels of exposure to industrial emissions, effects on pulmonary and cardiovascular functions in children with asthma may be difficult to detect over 10 consecutive days.",
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AU - Goldberg, Mark S.

AU - Wheeler, Amanda J.

AU - Plante, Céline

AU - Valois, Marie France

AU - Mallach, Gary

AU - Kauri, Lisa Marie

AU - Shutt, Robin

AU - Bartlett, Susan

AU - Raphoz, Marie

AU - Liu, Ling

PY - 2014

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N2 - Objective: The acute cardiorespiratory effects of air quality among children living in areas with considerable heavy industry have not been well investigated. We conducted a panel study of children with asthma living in proximity to an industrial complex housing two refineries in Montreal, Quebec, in order to assess associations between their personal daily exposure to air pollutants and changes in pulmonary function and selected indicators of cardiovascular health. Methods: Seventy-two children with asthma age 7-12 years in 2009-2010 participated in this panel study for a period of 10 consecutive days. They carried a small backpack for personal monitoring of sulphur dioxide (SO2), benzene, fine particles (PM2.5), nitrogen dioxide (NO2) and polycyclic aromatic hydrocarbons (PAHs) and underwent daily spirometry and cardiovascular testing (blood pressure, pulse rate and oxygen saturation). To estimate these associations, we used mixed regression models, adjusting for within-subject serial correlation, and for the effects of a number of personal and environmental variables (e.g., medication use, ethnicity, temperature). Results: Children with asthma involved in the study had relatively good pulmonary function test results (mean FEV1 compared to standard values: 89.8%, mean FVC: 97.6%, mean FEF25-75: 76.3%). Median diastolic, systolic blood pressures and oxygen saturation were 60/94mmHg and 99%, respectively. Median personal concentrations of pollutants were NO2, 5.5ppb; benzene, 2.1μg/m3; PM2.5, 5.7μg/m3; and total PAH, 130μg/m3. Most personal concentrations of SO2 were below the level of detection. No consistent associations were observed between cardio-pulmonary indices and personal exposure to PM2.5, NO2 and benzene, although there was a suggestion for a small decrease in respiratory function with total concentrations of PAHs (e.g., adjusted association with FVC: -9.9ml per interquartile range 95%CI: -23.4, 3.7). Conclusions: This study suggests that at low daily average levels of exposure to industrial emissions, effects on pulmonary and cardiovascular functions in children with asthma may be difficult to detect over 10 consecutive days.

AB - Objective: The acute cardiorespiratory effects of air quality among children living in areas with considerable heavy industry have not been well investigated. We conducted a panel study of children with asthma living in proximity to an industrial complex housing two refineries in Montreal, Quebec, in order to assess associations between their personal daily exposure to air pollutants and changes in pulmonary function and selected indicators of cardiovascular health. Methods: Seventy-two children with asthma age 7-12 years in 2009-2010 participated in this panel study for a period of 10 consecutive days. They carried a small backpack for personal monitoring of sulphur dioxide (SO2), benzene, fine particles (PM2.5), nitrogen dioxide (NO2) and polycyclic aromatic hydrocarbons (PAHs) and underwent daily spirometry and cardiovascular testing (blood pressure, pulse rate and oxygen saturation). To estimate these associations, we used mixed regression models, adjusting for within-subject serial correlation, and for the effects of a number of personal and environmental variables (e.g., medication use, ethnicity, temperature). Results: Children with asthma involved in the study had relatively good pulmonary function test results (mean FEV1 compared to standard values: 89.8%, mean FVC: 97.6%, mean FEF25-75: 76.3%). Median diastolic, systolic blood pressures and oxygen saturation were 60/94mmHg and 99%, respectively. Median personal concentrations of pollutants were NO2, 5.5ppb; benzene, 2.1μg/m3; PM2.5, 5.7μg/m3; and total PAH, 130μg/m3. Most personal concentrations of SO2 were below the level of detection. No consistent associations were observed between cardio-pulmonary indices and personal exposure to PM2.5, NO2 and benzene, although there was a suggestion for a small decrease in respiratory function with total concentrations of PAHs (e.g., adjusted association with FVC: -9.9ml per interquartile range 95%CI: -23.4, 3.7). Conclusions: This study suggests that at low daily average levels of exposure to industrial emissions, effects on pulmonary and cardiovascular functions in children with asthma may be difficult to detect over 10 consecutive days.

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