Associations between maternal cadmium exposure with risk of preterm birth and low after birth weight effect of mediterranean diet adherence on affected prenatal outcomes

Sarah Gonzalez-Nahm, Kiran Nihlani, John S. House, Rachel L. Maguire, Harlyn G. Skinner, Cathrine Hoyo

Research output: Contribution to journalArticlepeer-review

Abstract

Prenatal cadmium exposure at non-occupational levels has been associated with poor birth outcomes. The intake of essential metals, such as iron and selenium, may mitigate cadmium exposure effects. However, at high levels, these metals can be toxic. The role of dietary patterns rich in these metals is less studied. We used a linear and logistic regression in a cohort of 185 mother–infant pairs to assess if a Mediterranean diet pattern during pregnancy modified the associations between prenatal cadmium exposure and (1) birth weight and (2) preterm birth. We found that increased cadmium exposure during pregnancy was associated with lower birth weight (β =-210.4; 95% CI: -332.0, -88.8; p = 0.008) and preterm birth (OR = 0.11; 95% CI: 0.01, 0.72; p = 0.04); however, these associations were comparable in offspring born to women reporting high adherence to a Mediterranean diet (β =-274.95; 95% CI: -701.17, 151.26; p = 0.20) and those with low adherence (β =-64.76; 95% CI: -359.90, 230.37; p = 0.66). While the small sample size limits inference, our findings suggest that adherence to a Mediterranean dietary pattern may not mitigate cadmium exposure effects. Given the multiple organs targeted by cadmium and its slow excretion rate, larger studies are required to clarify these findings.

Original languageEnglish (US)
Article number90
Pages (from-to)1-12
Number of pages12
JournalToxics
Volume8
Issue number4
DOIs
StatePublished - Dec 2020
Externally publishedYes

Keywords

  • Birth weight
  • Cadmium
  • Diet pattern
  • Heavy metals
  • Mediterranean diet
  • Pregnancy
  • Preterm birth

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

Fingerprint Dive into the research topics of 'Associations between maternal cadmium exposure with risk of preterm birth and low after birth weight effect of mediterranean diet adherence on affected prenatal outcomes'. Together they form a unique fingerprint.

Cite this