Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects

The Atherosclerosis Risk in Communities (ARIC) study

Salim S. Virani, Ariel Brautbar, Brian C. Davis, Vijay Nambi, Ron C. Hoogeveen, A. Richey Sharrett, Josef Coresh, Thomas H. Mosley, Joel D. Morrisett, Diane J. Catellier, Aaron R. Folsom, Eric Boerwinkle, Christie M. Ballantyne

Research output: Contribution to journalArticle

Abstract

Background - On the basis of studies with limited statistical power, lipoprotein(a) [Lp(a)] is not considered a risk factor for cardiovascular disease (CVD) in blacks. We evaluated associations between Lp(a) and incident CVD events in blacks and whites in the Atherosclerosis Risk in Communities (ARIC) study. Methods and Results - Plasma Lp(a) was measured in blacks (n=3467) and whites (n=9851). Hazards ratios (HRs) for incident CVD events (coronary heart disease and ischemic strokes) were calculated. Lp(a) levels were higher with wider interindividual variation in blacks (median [interquartile range], 12.8 [7.1-21.7] mg/dL) than whites (4.3 [1.7-9.5] mg/dL; P10 to ≤20 mg/dL, >20 to ≤30 mg/dL, and >30 mg/dL. Conclusions - Lp(a) levels were positively associated with CVD events. Associations were at least as strong, with a larger range of Lp(a) concentrations, in blacks compared with whites.

Original languageEnglish (US)
Pages (from-to)241-249
Number of pages9
JournalCirculation
Volume125
Issue number2
DOIs
StatePublished - Jan 17 2012

Fingerprint

Lipoprotein(a)
Atherosclerosis
Cardiovascular Diseases
Coronary Disease
hydroquinone
Stroke

Keywords

  • cardiovascular diseases
  • ethnic groups
  • lipoproteins
  • race
  • risk factors

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects : The Atherosclerosis Risk in Communities (ARIC) study. / Virani, Salim S.; Brautbar, Ariel; Davis, Brian C.; Nambi, Vijay; Hoogeveen, Ron C.; Sharrett, A. Richey; Coresh, Josef; Mosley, Thomas H.; Morrisett, Joel D.; Catellier, Diane J.; Folsom, Aaron R.; Boerwinkle, Eric; Ballantyne, Christie M.

In: Circulation, Vol. 125, No. 2, 17.01.2012, p. 241-249.

Research output: Contribution to journalArticle

Virani, SS, Brautbar, A, Davis, BC, Nambi, V, Hoogeveen, RC, Sharrett, AR, Coresh, J, Mosley, TH, Morrisett, JD, Catellier, DJ, Folsom, AR, Boerwinkle, E & Ballantyne, CM 2012, 'Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects: The Atherosclerosis Risk in Communities (ARIC) study', Circulation, vol. 125, no. 2, pp. 241-249. https://doi.org/10.1161/CIRCULATIONAHA.111.045120
Virani, Salim S. ; Brautbar, Ariel ; Davis, Brian C. ; Nambi, Vijay ; Hoogeveen, Ron C. ; Sharrett, A. Richey ; Coresh, Josef ; Mosley, Thomas H. ; Morrisett, Joel D. ; Catellier, Diane J. ; Folsom, Aaron R. ; Boerwinkle, Eric ; Ballantyne, Christie M. / Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects : The Atherosclerosis Risk in Communities (ARIC) study. In: Circulation. 2012 ; Vol. 125, No. 2. pp. 241-249.
@article{f62c31cef7cb44ad8854343059b51234,
title = "Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects: The Atherosclerosis Risk in Communities (ARIC) study",
abstract = "Background - On the basis of studies with limited statistical power, lipoprotein(a) [Lp(a)] is not considered a risk factor for cardiovascular disease (CVD) in blacks. We evaluated associations between Lp(a) and incident CVD events in blacks and whites in the Atherosclerosis Risk in Communities (ARIC) study. Methods and Results - Plasma Lp(a) was measured in blacks (n=3467) and whites (n=9851). Hazards ratios (HRs) for incident CVD events (coronary heart disease and ischemic strokes) were calculated. Lp(a) levels were higher with wider interindividual variation in blacks (median [interquartile range], 12.8 [7.1-21.7] mg/dL) than whites (4.3 [1.7-9.5] mg/dL; P10 to ≤20 mg/dL, >20 to ≤30 mg/dL, and >30 mg/dL. Conclusions - Lp(a) levels were positively associated with CVD events. Associations were at least as strong, with a larger range of Lp(a) concentrations, in blacks compared with whites.",
keywords = "cardiovascular diseases, ethnic groups, lipoproteins, race, risk factors",
author = "Virani, {Salim S.} and Ariel Brautbar and Davis, {Brian C.} and Vijay Nambi and Hoogeveen, {Ron C.} and Sharrett, {A. Richey} and Josef Coresh and Mosley, {Thomas H.} and Morrisett, {Joel D.} and Catellier, {Diane J.} and Folsom, {Aaron R.} and Eric Boerwinkle and Ballantyne, {Christie M.}",
year = "2012",
month = "1",
day = "17",
doi = "10.1161/CIRCULATIONAHA.111.045120",
language = "English (US)",
volume = "125",
pages = "241--249",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects

T2 - The Atherosclerosis Risk in Communities (ARIC) study

AU - Virani, Salim S.

AU - Brautbar, Ariel

AU - Davis, Brian C.

AU - Nambi, Vijay

AU - Hoogeveen, Ron C.

AU - Sharrett, A. Richey

AU - Coresh, Josef

AU - Mosley, Thomas H.

AU - Morrisett, Joel D.

AU - Catellier, Diane J.

AU - Folsom, Aaron R.

AU - Boerwinkle, Eric

AU - Ballantyne, Christie M.

PY - 2012/1/17

Y1 - 2012/1/17

N2 - Background - On the basis of studies with limited statistical power, lipoprotein(a) [Lp(a)] is not considered a risk factor for cardiovascular disease (CVD) in blacks. We evaluated associations between Lp(a) and incident CVD events in blacks and whites in the Atherosclerosis Risk in Communities (ARIC) study. Methods and Results - Plasma Lp(a) was measured in blacks (n=3467) and whites (n=9851). Hazards ratios (HRs) for incident CVD events (coronary heart disease and ischemic strokes) were calculated. Lp(a) levels were higher with wider interindividual variation in blacks (median [interquartile range], 12.8 [7.1-21.7] mg/dL) than whites (4.3 [1.7-9.5] mg/dL; P10 to ≤20 mg/dL, >20 to ≤30 mg/dL, and >30 mg/dL. Conclusions - Lp(a) levels were positively associated with CVD events. Associations were at least as strong, with a larger range of Lp(a) concentrations, in blacks compared with whites.

AB - Background - On the basis of studies with limited statistical power, lipoprotein(a) [Lp(a)] is not considered a risk factor for cardiovascular disease (CVD) in blacks. We evaluated associations between Lp(a) and incident CVD events in blacks and whites in the Atherosclerosis Risk in Communities (ARIC) study. Methods and Results - Plasma Lp(a) was measured in blacks (n=3467) and whites (n=9851). Hazards ratios (HRs) for incident CVD events (coronary heart disease and ischemic strokes) were calculated. Lp(a) levels were higher with wider interindividual variation in blacks (median [interquartile range], 12.8 [7.1-21.7] mg/dL) than whites (4.3 [1.7-9.5] mg/dL; P10 to ≤20 mg/dL, >20 to ≤30 mg/dL, and >30 mg/dL. Conclusions - Lp(a) levels were positively associated with CVD events. Associations were at least as strong, with a larger range of Lp(a) concentrations, in blacks compared with whites.

KW - cardiovascular diseases

KW - ethnic groups

KW - lipoproteins

KW - race

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=84856101806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856101806&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.111.045120

DO - 10.1161/CIRCULATIONAHA.111.045120

M3 - Article

VL - 125

SP - 241

EP - 249

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 2

ER -