Associations Between Inflammation and Physical Function in African Americans and European Americans with Prevalent Cardiovascular Risk Factors

B. Gwen Windham, Steven R. Wilkening, Seth T. Lirette, Iftikhar J. Kullo, Stephen T. Turner, Michael E. Griswold, Thomas H. Mosley

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To examine associations between inflammation and physical function and potential mediation by white matter hyperintensities (WMHs) in African Americans (AAs) and European Americans (EAs). Design: Cross-sectional analysis using linear and logistic models with generalized estimating equations to account for family clustering, reporting results as regression coefficients (β) and odds ratios (ORs) adjusted for education, alcohol, exercise, body mass index, hypertension, diabetes mellitus, heart disease, cognition, ankle–brachial index, race (site), and supported interactions. Setting: Genetic Epidemiology Network of Arteriopathy-Genetics of Microangiopathic Brain Injury Study cohort. Participants: AA and EA sibships with two or more siblings with hypertension before age 60 (N = 1,960; 65% female, 51% AA, aged 26–91, 50% obese, 72% hypertensive). Measurements: Inflammation (C-reactive protein (CRP), interleukin-6 (IL6), soluble tumor necrosis factor receptors (sTNFRs) 1 and 2, WMH volume (cm3) according to magnetic resonance imaging), walking speed (cm/s) over 25 feet, and mobility difficulty (any self-reported difficulty walking half a mile). Results: In separate models, inflammatory markers were associated with walking speed (sTNFR1: β = −2.74, P

Original languageEnglish (US)
Pages (from-to)1448-1455
Number of pages8
JournalJournal of the American Geriatrics Society
Volume64
Issue number7
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Keywords

  • ethnicity
  • inflammation
  • physical function
  • white matter hyperintensity

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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