Associations between hOGG1 sequence variants and prostate cancer susceptibility

Jianfeng Xu; Siqun L. Zheng; Aubrey Turner; Sarah D. Isaacs; Kathy E. Wiley; Gregory A. Hawkins; Bao Li Chang; Eugene R. Bleecker; Patrick C. Walsh; Deborah A. Meyers; William B. Isaacs

Associations between hOGG1 sequence variants and prostate cancer susceptibility

Jianfeng Xu, Siqun L. Zheng, Aubrey Turner, Sarah D. Isaacs, Kathy E. Wiley, Gregory A. Hawkins, Bao Li Chang, Eugene R. Bleecker, Patrick C. Walsh, Deborah A. Meyers, William B. Isaacs

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygen species. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA. A population-based (245 cases and 222 controls) and family-based (159 hereditary prostate cancer families) association study was performed to test the hypothesis that sequence variants of hOGG1 increase susceptibility to prostate cancer. We found that the genotype frequency of two sequence variants (11657A/G and Ser326Cys) was significantly different between cases and controls. The association with 11657A/G is confirmed and strengthened by our family-based association study. These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1.

Original language	English (US)
Pages (from-to)	2253-2257
Number of pages	5
Journal	Cancer Research
Volume	62
Issue number	8
State	Published - Apr 15 2002

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Associations between hOGG1 sequence variants and prostate cancer susceptibility",

abstract = "8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygen species. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA. A population-based (245 cases and 222 controls) and family-based (159 hereditary prostate cancer families) association study was performed to test the hypothesis that sequence variants of hOGG1 increase susceptibility to prostate cancer. We found that the genotype frequency of two sequence variants (11657A/G and Ser326Cys) was significantly different between cases and controls. The association with 11657A/G is confirmed and strengthened by our family-based association study. These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1.",

author = "Jianfeng Xu and Zheng, {Siqun L.} and Aubrey Turner and Isaacs, {Sarah D.} and Wiley, {Kathy E.} and Hawkins, {Gregory A.} and Chang, {Bao Li} and Bleecker, {Eugene R.} and Walsh, {Patrick C.} and Meyers, {Deborah A.} and Isaacs, {William B.}",

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TY - JOUR

T1 - Associations between hOGG1 sequence variants and prostate cancer susceptibility

AU - Xu, Jianfeng

AU - Zheng, Siqun L.

AU - Turner, Aubrey

AU - Isaacs, Sarah D.

AU - Wiley, Kathy E.

AU - Hawkins, Gregory A.

AU - Chang, Bao Li

AU - Bleecker, Eugene R.

AU - Walsh, Patrick C.

AU - Meyers, Deborah A.

AU - Isaacs, William B.

PY - 2002/4/15

Y1 - 2002/4/15

N2 - 8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygen species. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA. A population-based (245 cases and 222 controls) and family-based (159 hereditary prostate cancer families) association study was performed to test the hypothesis that sequence variants of hOGG1 increase susceptibility to prostate cancer. We found that the genotype frequency of two sequence variants (11657A/G and Ser326Cys) was significantly different between cases and controls. The association with 11657A/G is confirmed and strengthened by our family-based association study. These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1.

AB - 8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygen species. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA. A population-based (245 cases and 222 controls) and family-based (159 hereditary prostate cancer families) association study was performed to test the hypothesis that sequence variants of hOGG1 increase susceptibility to prostate cancer. We found that the genotype frequency of two sequence variants (11657A/G and Ser326Cys) was significantly different between cases and controls. The association with 11657A/G is confirmed and strengthened by our family-based association study. These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1.

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Associations between hOGG1 sequence variants and prostate cancer susceptibility

Abstract

ASJC Scopus subject areas

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