Associations between hOGG1 sequence variants and prostate cancer susceptibility

Jianfeng Xu, Siqun L. Zheng, Aubrey Turner, Sarah D. Isaacs, Kathy E. Wiley, Gregory A. Hawkins, Bao Li Chang, Eugene R. Bleecker, Patrick C. Walsh, Deborah A. Meyers, William B. Isaacs

Research output: Contribution to journalArticle

Abstract

8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygen species. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA. A population-based (245 cases and 222 controls) and family-based (159 hereditary prostate cancer families) association study was performed to test the hypothesis that sequence variants of hOGG1 increase susceptibility to prostate cancer. We found that the genotype frequency of two sequence variants (11657A/G and Ser326Cys) was significantly different between cases and controls. The association with 11657A/G is confirmed and strengthened by our family-based association study. These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1.

Original languageEnglish (US)
Pages (from-to)2253-2257
Number of pages5
JournalCancer Research
Volume62
Issue number8
StatePublished - Apr 15 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Xu, J., Zheng, S. L., Turner, A., Isaacs, S. D., Wiley, K. E., Hawkins, G. A., Chang, B. L., Bleecker, E. R., Walsh, P. C., Meyers, D. A., & Isaacs, W. B. (2002). Associations between hOGG1 sequence variants and prostate cancer susceptibility. Cancer Research, 62(8), 2253-2257.