Abstract
Background/Aims: Some studies suggest that polymorphisms in angiotensin-converting enzyme (ACE), angiotensinogen (AGT), angiotensin II type I receptor (AGTR1) and angiotensin II type II receptor (AGTR2) genes may contribute to renal function variation. Methods: Genotyping for single nucleotide polymorphisms (SNPs) in these candidate genes was performed in 2,847 participants from four racial/ethnic groups (African American, Chinese, White and Hispanic) without known cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. SNP and haplotype analyses were performed to determine associations between genotypes and cross-sectional renal function measurements, including urine albumin excretion (UAE) and estimated glomerular filtration rate (EGFR) using serum creatinine and cystatin C. Results: Twenty-four ACE SNPs, 10 AGT SNPs, 15 AGTR1 SNPs and 6 AGTR2 SNPs were typed successfully. After adjusting for ancestry, age and gender, 3 SNPs (AGT M235T, AGT rs2148582 and AGTR1 rs2131127) showed associations with an empiric p value <0.05 with the same phenotype in multiple racial/ethnic groups, suggesting replication. The AGT M235T SNP has been shown previously to be associated with diabetic and hypertensive nephropathy. Conclusions: These data suggest that genetic polymorphisms in the renin-Angiotensin system are associated with renal phenotypes in the general population, but that many associations differ across racial/ethnic groups.
Original language | English (US) |
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Pages (from-to) | 156-162 |
Number of pages | 7 |
Journal | American Journal of Nephrology |
Volume | 32 |
Issue number | 2 |
DOIs | |
State | Published - 2010 |
Keywords
- Ace
- Agt
- Agtr1
- Agtr2
- Albuminuria
- Creatinine clearance epidemiology
- Genetics
- Renin-Angiotensin
ASJC Scopus subject areas
- Nephrology