Associations between Genetic Variants in the ACE, AGT, AGTR1 and AGTR2 Genes and Renal Function in the Multi-Ethnic Study of Atherosclerosis

Catherine Y. Campbell, Belle F. Fang, Xiuqing Guo, Carmen A. Peralta, Bruce M. Psaty, Stephen S. Rich, J Hunter Young, Josef Coresh, Holly J. Kramer, Jerome I. Rotter, Wendy S Post

Research output: Contribution to journalArticle

Abstract

Background/Aims: Some studies suggest that polymorphisms in angiotensin-converting enzyme (ACE), angiotensinogen (AGT), angiotensin II type I receptor (AGTR1) and angiotensin II type II receptor (AGTR2) genes may contribute to renal function variation. Methods: Genotyping for single nucleotide polymorphisms (SNPs) in these candidate genes was performed in 2,847 participants from four racial/ethnic groups (African American, Chinese, White and Hispanic) without known cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. SNP and haplotype analyses were performed to determine associations between genotypes and cross-sectional renal function measurements, including urine albumin excretion (UAE) and estimated glomerular filtration rate (eGFR) using serum creatinine and cystatin C. Results: Twenty-four ACE SNPs, 10 AGT SNPs, 15 AGTR1 SNPs and 6 AGTR2 SNPs were typed successfully. After adjusting for ancestry, age and gender, 3 SNPs (AGT M235T, AGT rs2148582 and AGTR1 rs2131127) showed associations with an empiric p value

Original languageEnglish (US)
Pages (from-to)156-162
Number of pages7
JournalAmerican Journal of Nephrology
Volume32
Issue number2
DOIs
StateAccepted/In press - Jul 1 2010

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Angiotensinogen
Peptidyl-Dipeptidase A
Single Nucleotide Polymorphism
Atherosclerosis
Kidney
Genes
Cystatin C
Angiotensin I
Angiotensin Receptors
Glomerular Filtration Rate
Hispanic Americans
Ethnic Groups
Angiotensin II
African Americans
Haplotypes
Albumins
Creatinine
Cardiovascular Diseases
Genotype
Urine

ASJC Scopus subject areas

  • Nephrology

Cite this

Associations between Genetic Variants in the ACE, AGT, AGTR1 and AGTR2 Genes and Renal Function in the Multi-Ethnic Study of Atherosclerosis. / Campbell, Catherine Y.; Fang, Belle F.; Guo, Xiuqing; Peralta, Carmen A.; Psaty, Bruce M.; Rich, Stephen S.; Young, J Hunter; Coresh, Josef; Kramer, Holly J.; Rotter, Jerome I.; Post, Wendy S.

In: American Journal of Nephrology, Vol. 32, No. 2, 01.07.2010, p. 156-162.

Research output: Contribution to journalArticle

Campbell, Catherine Y. ; Fang, Belle F. ; Guo, Xiuqing ; Peralta, Carmen A. ; Psaty, Bruce M. ; Rich, Stephen S. ; Young, J Hunter ; Coresh, Josef ; Kramer, Holly J. ; Rotter, Jerome I. ; Post, Wendy S. / Associations between Genetic Variants in the ACE, AGT, AGTR1 and AGTR2 Genes and Renal Function in the Multi-Ethnic Study of Atherosclerosis. In: American Journal of Nephrology. 2010 ; Vol. 32, No. 2. pp. 156-162.
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